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HNF1 homeobox A
Summary
- Gene Symbol
-
- HNF1A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Alternative splicing
- DNA-binding
- Diabetes mellitus
- Disease variant
- Homeobox
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glucose import | ||
| pancreas development | ||
| regulation of transcription by RNA polymerase II | ||
| glucose homeostasis | ||
| insulin secretion |
GO Hierarchy
biological process
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA binding | ||
| protein heterodimerization activity | ||
| protein dimerization activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Hepatocyte nuclear factor 1
- Functional Category
-
- I: Lipid transport and metabolism
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin secretion |
| liver development |
| pancreas development |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050524 | maturity-onset diabetes of the young | |
| DOID:0050868 | hepatocellular adenoma | |
| DOID:0110757 | type 1 diabetes mellitus 20 | |
| DOID:0111102 | maturity-onset diabetes of the young type 3 | |
| DOID:0111366 | familial hepatic adenoma | |
| DOID:10591 | pre-eclampsia | |
| DOID:10603 | glucose intolerance | |
| DOID:11714 | gestational diabetes | |
| DOID:13619 | extrahepatic cholestasis | |
| DOID:3393 | coronary artery disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 21405 | MGI:98504 | MOUSE45373 | ||
| 24817 | RGD:3828 | RATNO05702 | ||
| 266961 | ZFIN:ZDB-GENE-021206-12 | |||
| 378589 | Xenbase:XB-GENE-865049 | |||
| 378590 | Xenbase:XB-GENE-6252640 | |||
| 486303 | CANLF10389 | |||
| 503578 | BOVIN09666 | |||
| 744150 | 9598_0:0033cd | PANTR07095 | ||
| 100018223 | MONDO18714 | |||
| 100049993 | HORSE41783 |
