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3-ketodihydrosphingosine reductase

Summary

Gene Symbol

KDSR

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 700476
KEGG Gene ID: mcc:700476
PubChem: 700476

Annotation

Keyword

Endoplasmic reticulum
NADP
Oxidoreductase
Reference proteome
Signal
Sphingolipid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
F7HPT5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sphingolipid biosynthetic process	IEA	22301074 30032202
3-keto-sphinganine metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
3-dehydrosphinganine reductase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-dehydrosphinganine reductase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

KEGG BRITE Database

Orthology

K04708

Name

3-dehydrosphinganine reductase [EC:1.1.1.102]

References

15328338

Rhea

sphinganine + NADP⁺

H⁺ + NADPH + 3-oxosphinganine

Enzyme

1.1.1.102

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP014285
Gene Name: 3-ketodihydrosphingosine reductase

Ortholog

Displaying entries **21 - 30** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100774578			CRIGR09424
Otolemur garnettii	100954919			OTOGA13226
Papio anubis	101026535	9555_0:00460d		PAPAN17114
Saimiri boliviensis boliviensis	101051050			SAIBB10252
Takifugu rubripes	101069480			TAKRU31724
Gorilla gorilla gorilla	101136495			GORGO14121
Oryzias latipes	101163276			ORYLA06973
Tursiops truncatus	101335884			TURTR13814
Octodon degus	101573494			OCTDE15479
Jaculus jaculus	101604245			JACJA05945

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024