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3-ketodihydrosphingosine reductase

Summary

Gene Symbol

KDSR

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 700476
KEGG Gene ID: mcc:700476
PubChem: 700476

Annotation

Keyword

Endoplasmic reticulum
NADP
Oxidoreductase
Reference proteome
Signal
Sphingolipid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
F7HPT5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sphingolipid biosynthetic process	IEA	22301074 30032202
3-keto-sphinganine metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

3-keto-sphinganine metabolic process

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

sphingoid metabolic process [inference]

3-keto-sphinganine metabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
3-dehydrosphinganine reductase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-dehydrosphinganine reductase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

KEGG BRITE Database

Orthology

K04708

Name

3-dehydrosphinganine reductase [EC:1.1.1.102]

References

15328338

Rhea

sphinganine + NADP⁺

H⁺ + NADPH + 3-oxosphinganine

Enzyme

1.1.1.102

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP014285
Gene Name: 3-ketodihydrosphingosine reductase

Ortholog

Displaying entries **51 - 60** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Propithecus coquereli	105811150			PROCO23765
Dipodomys ordii	105987607			DIPOR06738
Salmo salar	106569188			SALSA35191
Equus asinus asinus	106832882			EQUAS01343
Sinocyclocheilus grahami	107559381			SINGR67097
Sinocyclocheilus grahami	107593837			SINGR09185
Rhinopithecus bieti	108526387	61621_0:0008b1
Cyprinus carpio carpio	109050383			CYPCA69569
Piliocolobus tephrosceles	111528446	591936_0:0040ec
Theropithecus gelada	112611363	9565_0:004263

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Last updated: December 9, 2024