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DNA topoisomerase I

Summary

Gene Symbol

TOP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7150

PubChem

7150

Alliance of Genome Resources

HGNC:11986

Annotation

Keyword

3D-structure
Acetylation
Biological rhythms
Chromosomal rearrangement
Coiled coil
DNA-binding
Direct protein sequencing
Host-virus interaction
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Topoisomerase
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9BVT2
P11387	DNA topoisomerase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
peptidyl-serine phosphorylation	IMP	9611241
DNA replication	IBA
circadian rhythm	IEP	22904072
response to xenobiotic stimulus	IEP	16127745
circadian regulation of gene expression	IMP	22904072

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation [inference]

peptidyl-serine phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular process [inference]

cell death [inference]

programmed cell death

cell cycle process [inference]

chromosome segregation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation [inference]

peptidyl-serine phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cell division [inference]

embryonic cleavage

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA topological change

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

rhythmic process [inference]

circadian rhythm

circadian regulation of gene expression

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
perikaryon	IEA
nuclear chromosome	IDA	9049244
male germ cell nucleus	IEA
P-body	IDA	12878161
nucleoplasm	IDA IMP TAS	14654701 9049244

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome

nucleolus

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome

nucleolus

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10352183 12878161 15448168 17234752 17314511 20195357 23213405 26030138 29248492 34591642 8567649
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	22904072
DNA binding	EXP IDA IMP	10497031 11283003 17355975
chromatin binding	IDA	9049244
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA IDA IMP	14594810 14654701 17355975 8567649 8631793 8631794 9611241

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

isomerase activity [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

binding [inference]

protein binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA binding

double-stranded DNA binding

supercoiled DNA binding

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA topoisomerase I

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
DNA topoisomerase type I (single strand cut, ATP-independent) activity
DNA topological change
chromosome segregation
isomerase activity

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InterPro
DNA breaking-rejoining enzyme, catalytic core
DNA topoisomerase I, DNA binding, N-terminal domain 1
DNA topoisomerase I, DNA binding, N-terminal domain 2
DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
DNA topoisomerase I, DNA binding, eukaryotic-type
DNA topoisomerase I, DNA-binding domain
DNA topoisomerase I, active site
DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
DNA topoisomerase I, catalytic core, alpha/beta subdomain
DNA topoisomerase I, catalytic core, eukaryotic-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	734592		Xenbase:XB-GENE-5814534
Saccharomyces cerevisiae S288C	854156		SGD:S000005366
Monodelphis domestica	100032710			MONDO08587
Ornithorhynchus anatinus	100078817			ORNAN26214
Taeniopygia guttata	100222949			TAEGU12493
Oryctolagus cuniculus	100349705			RABIT14695
Xenopus tropicalis	100380116		Xenbase:XB-GENE-5814502
Callithrix jacchus	100397121			CALJA32857
Pongo abelii	100452064	9601_0:004d06		PONAB20575
Sus scrofa	100518587			PIGXX11760

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements