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DNA topoisomerase I

Summary

Gene Symbol

TOP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7150

PubChem

7150

Alliance of Genome Resources

HGNC:11986

Annotation

Keyword

3D-structure
Acetylation
Biological rhythms
Chromosomal rearrangement
Coiled coil
DNA-binding
Direct protein sequencing
Host-virus interaction
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Topoisomerase
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9BVT2
P11387	DNA topoisomerase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
peptidyl-serine phosphorylation	IMP	9611241
DNA replication	IBA
circadian rhythm	IEP	22904072
response to xenobiotic stimulus	IEP	16127745
circadian regulation of gene expression	IMP	22904072

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation [inference]

peptidyl-serine phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular process [inference]

cell death [inference]

programmed cell death

cell cycle process [inference]

chromosome segregation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation [inference]

peptidyl-serine phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cell division [inference]

embryonic cleavage

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA topological change

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

rhythmic process [inference]

circadian rhythm

circadian regulation of gene expression

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

circadian regulation of gene expression

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
perikaryon	IEA
nuclear chromosome	IDA	9049244
male germ cell nucleus	IEA
P-body	IDA	12878161
nucleoplasm	IDA IMP TAS	14654701 9049244

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome

nucleolus

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

nuclear chromosome

nucleolus

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

P-body

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10352183 12878161 15448168 17234752 17314511 20195357 23213405 26030138 29248492 34591642 8567649
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	22904072
DNA binding	EXP IDA IMP	10497031 11283003 17355975
chromatin binding	IDA	9049244
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA IDA IMP	14594810 14654701 17355975 8567649 8631793 8631794 9611241

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

isomerase activity [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

binding [inference]

protein binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA binding

double-stranded DNA binding

supercoiled DNA binding

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA topoisomerase I

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
DNA topoisomerase type I (single strand cut, ATP-independent) activity
DNA topological change
chromosome segregation
isomerase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
DNA breaking-rejoining enzyme, catalytic core
DNA topoisomerase I, DNA binding, N-terminal domain 1
DNA topoisomerase I, DNA binding, N-terminal domain 2
DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
DNA topoisomerase I, DNA binding, eukaryotic-type
DNA topoisomerase I, DNA-binding domain
DNA topoisomerase I, active site
DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
DNA topoisomerase I, catalytic core, alpha/beta subdomain
DNA topoisomerase I, catalytic core, eukaryotic-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 77 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Gorilla gorilla gorilla	101134131	9595_0:005358
Oryzias latipes	101164052		ORYLA14298
Tursiops truncatus	101331601		TURTR05209
Octodon degus	101562031		OCTDE08713
Jaculus jaculus	101606920		JACJA21196
Mustela putorius furo	101685852		MUSPF15987
Heterocephalus glaber	101704241		HETGA09551
Ficedula albicollis	101811283		FICAL08219
Macaca fascicularis	101866499		MACFA01673
Ictidomys tridecemlineatus	101955598		ICTTR02219

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements