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tumor protein p53
Summary
- Gene Symbol
-
- TP53
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative promoter usage
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell cycle
- Cytoplasm
- Cytoskeleton
- DNA-binding
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Isopeptide bond
- Li-Fraumeni syndrome
- Metal-binding
- Methylation
- Mitochondrion
- Necrosis
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repressor
- Transcription regulation
- Tumor suppressor
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A087WT22 |
|
| H2EHT1 |
|
| A0A087WXZ1 |
|
| P04637 |
|
| K7PPA8 |
|
| A0A087X1Q1 |
|
| Q53GA5 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to ischemia | ||
| DNA damage response | ||
| neuroblast proliferation |
GO Hierarchy
- viral process
- negative regulation of cell growth
- negative regulation of cell growth
biological process
immune system process [inference]
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cell activation [inference]
signal transduction [inference]
intracellular signal transduction [inference]
apoptotic signaling pathway [inference]
cellular metabolic process [inference]
cellular response to stimulus [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
response to stress [inference]
response to chemical [inference]
cellular response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of DNA metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of programmed cell death [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell cycle [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
intracellular signal transduction [inference]
apoptotic signaling pathway [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of programmed cell death [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell cycle [inference]
regulation of cellular component organization [inference]
regulation of cell cycle
regulation of mitotic cell cycle [inference]
regulation of cell cycle process [inference]
negative regulation of cell cycle process [inference]
regulation of cell cycle phase transition [inference]
negative regulation of cell cycle [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nuclear body | ||
| endoplasmic reticulum | ||
| cytosol | ||
| cytoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II-specific DNA-binding transcription factor binding | ||
| DNA binding | ||
| general transcription initiation factor binding | ||
| core promoter sequence-specific DNA binding | ||
| DNA-binding transcription factor activity |
GO Hierarchy
molecular function
binding [inference]
protein binding
organic cyclic compound binding [inference]
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12930 | dilated cardiomyopathy | |
| DOID:1350 | paranasal sinus benign neoplasm | |
| DOID:13544 | low tension glaucoma | |
| DOID:1380 | endometrial cancer | |
| DOID:14566 | disease of cellular proliferation | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:1749 | squamous cell carcinoma | |
| DOID:1793 | pancreatic cancer | |
| DOID:1909 | melanoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103660368 | URSMA20986 | ||
| 114039336 | VOMUR27059 | ||
| 113878373 | BOBOX14311 | ||
| 105877486 | MICMU08633 | ||
| 100963622 | OTOGA10899 | ||
| 102005455 | CHILA16183 | ||
| 101043647 | SAIBB15416 | ||
| 101957738 | ICTTR16589 | ||
| 101609339 | JACJA21133 | ||
| 117013763 | RHIFE07467 |
