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MIRAGE
C-C motif chemokine receptor 2
Summary
- Gene Symbol
-
- CCR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Host-virus interaction
- Inflammatory response
- Phosphoprotein
- Reference proteome
- Sulfation
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P41597 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| blood vessel remodeling | ||
| dendritic cell chemotaxis | ||
| monocyte chemotaxis | ||
| regulation of T cell cytokine production | ||
| positive regulation of T-helper 1 type immune response |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte migration [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of locomotion [inference]
regulation of chemotaxis [inference]
regulation of cell motility [inference]
regulation of cell migration [inference]
regulation of leukocyte migration [inference]
positive regulation of cell migration [inference]
positive regulation of cell motility [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of transmembrane transport [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cell motility [inference]
regulation of cell migration [inference]
regulation of leukocyte migration [inference]
positive regulation of cell migration [inference]
positive regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| fibrillar center | ||
| cytoplasm | ||
| cytoplasm | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| chemokine receptor activity | ||
| protein binding | ||
| C-C chemokine receptor activity | ||
| C-C chemokine binding | ||
| CCR2 chemokine receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- c-C chemokine receptor type 5
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- P: Inorganic ion transport and metabolism
| InterPro |
|---|
| Chemokine receptor family |
| G protein-coupled receptor, rhodopsin-like |
| GPCR, rhodopsin-like, 7TM |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:106 | pleural tuberculosis | |
| DOID:11335 | sarcoidosis | |
| DOID:11716 | prediabetes syndrome | |
| DOID:12574 | posterior uveitis | |
| DOID:12732 | intermediate uveitis | |
| DOID:13378 | Kawasaki disease | |
| DOID:1474 | aggressive periodontitis | |
| DOID:1555 | urticaria |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 539002 | BOVIN17983 | ||
| 574098 | MACMU28250 | ||
| 729230 | Xenbase:XB-GENE-6255338 | ||
| 791973 | WB:WBGene00011578 | ||
| 100048936 | HORSE12247 | ||
| 100219731 | TAEGU18327 | ||
| 100398782 | CALJA11853 | ||
| 100460754 | PONAB25208 | ||
| 100484065 | AILME19346 | ||
| 100557191 | ANOCA15012 |
