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chemokine (C-X-C motif) receptor 3, tandem duplicate 2

Summary

Gene Symbol

cxcr3.2

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

791973

PubChem

791973

Alliance of Genome Resources

ZFIN:ZDB-GENE-041114-186

Annotation

Keyword

Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Innate immunity
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
E9QJ73

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IEA
macrophage activation involved in immune response	IMP	25573892
chemotaxis	IEA
signal transduction	IEA
immune system process	IEA

GO Hierarchy

biological process

immune system process

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

leukocyte migration involved in immune response

immune response

innate immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation [inference]

macrophage activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

leukocyte migration [inference]

leukocyte migration involved in immune response

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation [inference]

macrophage activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte migration involved in immune response

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

macrophage chemotaxis

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation [inference]

macrophage activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

macrophage chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
external side of plasma membrane	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
C-C chemokine receptor activity	IBA
C-C chemokine binding	IBA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:0050073	invasive aspergillosis	Alliance of Genome Resources
DOID:13406	pulmonary sarcoidosis	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:418	systemic scleroderma	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:437	myasthenia gravis	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources