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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
tyrosine kinase 2
Summary
- Gene Symbol
-
- TYK2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| P29597 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of NK T cell proliferation | ||
| positive regulation of T-helper 17 type immune response | ||
| positive regulation of protein localization to nucleus | ||
| cellular response to virus | ||
| type I interferon-mediated signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| cytoplasmic side of plasma membrane | ||
| interleukin-23 receptor complex | ||
| extrinsic component of plasma membrane | ||
| nucleus |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein tyrosine kinase activity | ||
| growth hormone receptor binding | ||
| non-membrane spanning protein tyrosine kinase activity | ||
| type 1 angiotensin receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- protein kinase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| FERM domain |
| Protein kinase domain |
| Protein kinase-like domain superfamily |
| SH2 domain superfamily |
| Serine-threonine/tyrosine-protein kinase, catalytic domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111989 | immunodeficiency 35 | |
| DOID:14566 | disease of cellular proliferation | |
| DOID:2531 | hematologic cancer | |
| DOID:9970 | obesity |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 100715734 | CAVPO25386 | |||
| 100760469 | CRIGR06511 | |||
| 100927743 | SARHA04193 | |||
| 100962299 | OTOGA05163 | |||
| 100979090 | 9597_0:004cca | PANPA19466 | ||
| 101020681 | PAPAN23568 | |||
| 101080190 | TAKRU42548 | |||
| 101090171 | FELCA03029 | |||
| 101129051 | 9595_0:00504c | GORGO15214 | ||
| 101155851 | ORYLA16563 |
