valosin containing protein

Summary
Gene Symbol
  • VCP
Aliases
  • CDC48
  • IBMPFD
  • TERA
  • p97
  • transitional endoplasmic reticulum ATPase
Organism
Homo sapiens (human)
NCBI Gene
7415
HGNC
12666
PubChem
7415
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Amyotrophic lateral sclerosis
  • Autophagy
  • Charcot-Marie-Tooth disease
  • Cytoplasm
  • DNA repair
  • Direct protein sequencing
  • Disease variant
  • Endoplasmic reticulum
  • Hydrolase
  • Isopeptide bond
  • Lipid-binding
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Transport
  • Ubl conjugation
  • Ubl conjugation pathway
Proteins
Displaying 1 entry
UniProt Protein Name
P55072
  • 15S Mg(2+)-ATPase p97 subunit
  • Valosin-containing protein
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
ATPase
Functional Category
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Human Protein Atlas
ENSG00000165280

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Disease
Disease Ontology
Displaying all 10 entries
DO ID Disease Name Source
DOID:0050881 inclusion body myopathy with Paget disease of bone and frontotemporal dementia
DOID:0060205 frontotemporal dementia and/or amyotrophic lateral sclerosis 6
DOID:0110168 Charcot-Marie-Tooth disease type 2Y
DOID:0111385 inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
DOID:1289 neurodegenerative disease
DOID:1307 dementia
DOID:3429 inclusion body myositis
DOID:5408 Paget's disease of bone
DOID:5426 primary ovarian insufficiency
DOID:9255 frontotemporal dementia
The Human Phenotype Ontology
Displaying entries 1 - 10 of 212 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000020 Urinary incontinence
HP:0000217 Xerostomia
HP:0000474 Thickened nuchal skin fold
HP:0000508 Ptosis
HP:0000518 Cataract
HP:0000605 Supranuclear gaze palsy
HP:0000708 Atypical behavior
HP:0000709 Psychosis
HP:0000710 Hyperorality
Displaying entries 1 - 10 of 11 in total
Disease ID Disease Name
OMIM:167320
  • inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1
ORPHA:435387
  • Charcot-Marie-Tooth disease type 2Y
ORPHA:329478
  • adult-onset distal myopathy due to VCP mutation
ORPHA:100070
  • progressive non-fluent aphasia
ORPHA:803
  • amyotrophic lateral sclerosis
  • frontotemporal dementia and/or amyotrophic lateral sclerosis 3
ORPHA:275872
  • frontotemporal dementia with motor neuron disease
ORPHA:52430
  • inclusion body myopathy with Paget disease of bone and frontotemporal dementia
OMIM:616687
  • Charcot-Marie-Tooth disease type 2Y
ORPHA:329475
  • spastic paraplegia-Paget disease of bone syndrome
OMIM:613954
  • frontotemporal dementia and/or amyotrophic lateral sclerosis 6

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.1.1

Last updated: February 17, 2025