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glucosamine (N-acetyl)-6-sulfatase

Summary

Gene Symbol

Gns

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

75612

PubChem

75612

Alliance of Genome Resources

MGI:1922862

Annotation

Keyword

Calcium
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BFR4	Glucosamine-6-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
keratan sulfate catabolic process	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
lysosome	IDA	29514215

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine-6-sulfatase activity	IBA IEA ISO
metal ion binding	IEA
glycosaminoglycan binding	IBA IEA ISO
sulfate binding	IEA ISO
sulfuric ester hydrolase activity	ISO	15962010

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity

N-acetylglucosamine-6-sulfatase activity

binding [inference]

ion binding [inference]

anion binding [inference]

sulfate binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

sulfur compound binding [inference]

sulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acetylglucosamine-6-sulfatase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
N-acetylglucosamine-6-sulfatase activity
glycosaminoglycan binding
glycosaminoglycan metabolic process
hydrolase activity
metal ion binding

Displaying **all 4** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
N-acetylglucosamine-6-sulfatase
Sulfatase, N-terminal
Sulfatase, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111402	mucopolysaccharidosis type IIID	Alliance of Genome Resources
DOID:12801	mucopolysaccharidosis III	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Taeniopygia guttata	100228596			TAEGU08760
Oryctolagus cuniculus	100359029			RABIT10511
Callithrix jacchus	100400424			CALJA46040
Pongo abelii	100434320			PONAB04733
Ailuropoda melanoleuca	100484359			AILME11963
Anolis carolinensis	100554106			ANOCA07179
Nomascus leucogenys	100581183			NOMLE03242
Sus scrofa	100623722			PIGXX25750
Loxodonta africana	100666611			LOXAF19639
Oreochromis niloticus	100691814			ORENI24104

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024