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glucosamine (N-acetyl)-6-sulfatase

Summary

Gene Symbol

Gns

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

75612

PubChem

75612

Alliance of Genome Resources

MGI:1922862

Annotation

Keyword

Calcium
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BFR4	Glucosamine-6-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
keratan sulfate catabolic process	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
lysosome	IDA	29514215

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine-6-sulfatase activity	IBA IEA ISO
metal ion binding	IEA
glycosaminoglycan binding	IBA IEA ISO
sulfate binding	IEA ISO
sulfuric ester hydrolase activity	ISO	15962010

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity

N-acetylglucosamine-6-sulfatase activity

binding [inference]

ion binding [inference]

anion binding [inference]

sulfate binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

sulfur compound binding [inference]

sulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acetylglucosamine-6-sulfatase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
N-acetylglucosamine-6-sulfatase activity
glycosaminoglycan binding
glycosaminoglycan metabolic process
hydrolase activity
metal ion binding

Displaying **all 4** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
N-acetylglucosamine-6-sulfatase
Sulfatase, N-terminal
Sulfatase, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111402	mucopolysaccharidosis type IIID	Alliance of Genome Resources
DOID:12801	mucopolysaccharidosis III	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ictidomys tridecemlineatus	101974489	43179_0:0008d5		ICTTR13337
Microtus ochrogaster	101984390	79684_0:002a7d
Chinchilla lanigera	102022365	34839_0:002ccf
Latimeria chalumnae	102349411			LATCH18040
Pelodiscus sinensis	102457294			PELSI09716
Peromyscus maniculatus bairdii	102913666	230844_0:00425f
Astyanax mexicanus	103022579			ASTMX08549
Callorhinchus milii	103186133			CALMI33869
Chlorocebus sabaeus	103238645			CHLSB02398
Ursus maritimus	103656835			URSMA11659

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024