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glucosamine (N-acetyl)-6-sulfatase

Summary

Gene Symbol

Gns

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

75612

PubChem

75612

Alliance of Genome Resources

MGI:1922862

Annotation

Keyword

Calcium
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BFR4	Glucosamine-6-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
keratan sulfate catabolic process	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

keratan sulfate catabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate catabolic process

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

keratan sulfate catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
lysosome	IDA	29514215

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine-6-sulfatase activity	IBA IEA ISO
metal ion binding	IEA
glycosaminoglycan binding	IBA IEA ISO
sulfate binding	IEA ISO
sulfuric ester hydrolase activity	ISO	15962010

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity

N-acetylglucosamine-6-sulfatase activity

binding [inference]

ion binding [inference]

anion binding [inference]

sulfate binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

sulfur compound binding [inference]

sulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acetylglucosamine-6-sulfatase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
N-acetylglucosamine-6-sulfatase activity
glycosaminoglycan binding
glycosaminoglycan metabolic process
hydrolase activity
metal ion binding

Displaying **all 4** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
N-acetylglucosamine-6-sulfatase
Sulfatase, N-terminal
Sulfatase, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111402	mucopolysaccharidosis type IIID	Alliance of Genome Resources
DOID:12801	mucopolysaccharidosis III	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Equus asinus asinus	106824381			EQUAS16581
Marmota marmota marmota	107140090	9994_0:0001ec
Sinocyclocheilus grahami	107579806			SINGR104900
Sinocyclocheilus grahami	107583955			SINGR12899
Rhinopithecus bieti	108529983			RHIBE30061
Cyprinus carpio carpio	109071638			CYPCA33479
Cyprinus carpio carpio	109071669			CYPCA62333
Crocodylus porosus	109315540			CROPO04789
Castor canadensis	109689473	51338_0:0021ab
Mus caroli	110302812	10089_0:002de4

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024