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discoidin domain receptor tyrosine kinase 1

Summary

Gene Symbol

DDR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

780

PubChem

780

Alliance of Genome Resources

HGNC:2730

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Lactation
Metal-binding
Phosphoprotein
Pregnancy
Proteomics identification
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q96T62
A0A024RCQ1
A0A0A0MSX3
Q96T61
Q08345	CD167 antigen-like family member A Cell adhesion kinase Discoidin receptor tyrosine kinase HGK2 Mammary carcinoma kinase 10 Protein-tyrosine kinase 3A Protein-tyrosine kinase RTK-6 TRK E Tyrosine kinase DDR Tyrosine-protein kinase CAK

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
regulation of extracellular matrix disassembly	IMP	12065315
embryo implantation	IEA
cell population proliferation	IEA
mammary gland alveolus development	IEA
positive regulation of neuron projection development	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion [inference]

smooth muscle cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cell population proliferation

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

peptidyl-tyrosine phosphorylation [inference]

peptidyl-tyrosine autophosphorylation

protein autophosphorylation

peptidyl-tyrosine autophosphorylation

cell motility [inference]

cell migration [inference]

muscle cell migration [inference]

smooth muscle cell migration

wound healing, spreading of cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

axon development

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

multicellular organism development

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in mammary gland duct morphogenesis

anatomical structure development [inference]

multicellular organism development

animal organ development [inference]

sensory organ development [inference]

ear development

mammary gland alveolus development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

lactation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

lactation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
receptor complex	IBA IDA	23382219
plasma membrane	IBA TAS
extracellular space	HDA	16502470
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16337946 18190796 32296183 33961781 35384245
protein tyrosine kinase collagen receptor activity	IBA IDA	21044884 9659899
metal ion binding	IEA
transmembrane receptor protein tyrosine kinase activity	TAS	9659899
collagen binding	IBA IDA IMP	12065315 9659899

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

collagen binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

protein tyrosine kinase collagen receptor activity

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Discoidin domain-containing receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
collagen binding
positive regulation of neuron projection development
protein tyrosine kinase collagen receptor activity

Displaying **all 6** entries
InterPro
Coagulation factor 5/8 C-terminal domain
Discoidin domain-containing receptor 1/2, DS-like domain
Galactose-binding-like domain superfamily
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0050156	idiopathic pulmonary fibrosis	Alliance of Genome Resources
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:12351	alcoholic hepatitis	Alliance of Genome Resources
DOID:14018	alcoholic liver cirrhosis	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:3347	osteosarcoma	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12305		MGI:99216	MOUSE20974
Rattus norvegicus	25678		RGD:2252	RATNO21889
Caenorhabditis elegans	180622		WB:WBGene00017381
Xenopus laevis	398981		Xenbase:XB-GENE-864807
Pan troglodytes	462548	9598_0:001bd8
Macaca mulatta	714233			MACMU34871
Drosophila melanogaster	3346209		FB:FBgn0053531
Drosophila melanogaster	5740323		FB:FBgn0085409
Danio rerio	100007346		ZFIN:ZDB-GENE-060323-2	DANRE11202
Monodelphis domestica	100024433			MONDO10258

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements