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sodium voltage-gated channel alpha subunit 9

Summary

Gene Symbol

Scn9a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

78956

PubChem

78956

Alliance of Genome Resources

RGD:69368

Annotation

Keyword

Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
O08562	Peripheral sodium channel 1 Sodium channel protein type IX subunit alpha Voltage-gated sodium channel subunit alpha Nav1.7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEA ISO
behavioral response to pain	IEA ISO
behavioral response to formalin induced pain	IMP	31550995
detection of mechanical stimulus involved in sensory perception	IEA ISO
sensory perception of pain	ISO ISS

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

behavior [inference]

chemosensory behavior [inference]

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

behavioral response to pain

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

post-embryonic development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to chemical [inference]

response to toxic substance

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception of pain [inference]

detection of temperature stimulus involved in sensory perception of pain

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission [inference]

rhythmic excitation

negative regulation of biological process [inference]

negative regulation of action potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission [inference]

rhythmic excitation

regulation of action potential [inference]

negative regulation of action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

membrane depolarization [inference]

membrane depolarization during action potential

regulation of action potential [inference]

negative regulation of action potential

Displaying **all 5** entries
GO Term	Evidence Code	PMID
axon terminus	IEA ISO ISS
voltage-gated sodium channel complex	IBA IEA
plasma membrane	ISO
axon	IBA IDA	21118538
node of Ranvier	IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sodium ion binding
voltage-gated sodium channel activity	IBA IEA ISO ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium channel protein type 9 subunit alpha

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060170	generalized epilepsy with febrile seizures plus	Alliance of Genome Resources
DOID:0080422	Dravet syndrome	Alliance of Genome Resources
DOID:0111294	generalized epilepsy with febrile seizures plus 2	Alliance of Genome Resources
DOID:0111537	paroxysmal extreme pain disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:9240	erythromelalgia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6335		HGNC:10597	HUMAN65365
Mus musculus	20274	10090_1:000917	MGI:107636	MOUSE31874
Drosophila melanogaster	32619		FB:FBgn0285944
Pan troglodytes	459704			PANTR29024
Bos taurus	533065			BOVIN24148
Danio rerio	559447		ZFIN:ZDB-GENE-060906-1
Macaca mulatta	574119			MACMU06713
Macaca mulatta	704414			MACMU06713
Saccharomyces cerevisiae S288C	853131		SGD:S000003449
Oryctolagus cuniculus	100009210			RABIT11735