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Guidelines

MIRAGE

sodium voltage-gated channel alpha subunit 9

Summary

Gene Symbol

Scn9a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

78956

PubChem

78956

Alliance of Genome Resources

RGD:69368

Annotation

Keyword

Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
O08562	Peripheral sodium channel 1 Sodium channel protein type IX subunit alpha Voltage-gated sodium channel subunit alpha Nav1.7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
inflammatory response	ISO
inflammatory response	IEA
circadian rhythm	ISO
circadian rhythm	IEA
response to toxic substance	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

behavior [inference]

chemosensory behavior [inference]

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

behavioral response to pain

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

post-embryonic development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

response to chemical [inference]

response to toxic substance

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception of pain [inference]

detection of temperature stimulus involved in sensory perception of pain

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission [inference]

rhythmic excitation

negative regulation of biological process [inference]

negative regulation of action potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

rhythmic synaptic transmission [inference]

rhythmic excitation

regulation of action potential [inference]

negative regulation of action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

membrane depolarization [inference]

membrane depolarization during action potential

regulation of action potential [inference]

negative regulation of action potential

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	IBA
voltage-gated sodium channel complex	IEA
plasma membrane	ISO
axon	IDA	21118538
axon	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	ISS
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IBA
voltage-gated sodium channel activity	IEA
sodium ion binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium channel protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 3** entries
InterPro
Ion transport domain
Voltage-dependent channel domain superfamily
Voltage-gated cation channel calcium and sodium

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	773	SGD:S000003449
Saccharomyces cerevisiae S288C	774	SGD:S000003449
Saccharomyces cerevisiae S288C	775	SGD:S000003449
Saccharomyces cerevisiae S288C	776	SGD:S000003449
Saccharomyces cerevisiae S288C	777	SGD:S000003449
Saccharomyces cerevisiae S288C	778	SGD:S000003449
Saccharomyces cerevisiae S288C	779	SGD:S000003449
Xenopus tropicalis	6323	Xenbase:XB-GENE-978019
Xenopus tropicalis	6326	Xenbase:XB-GENE-978019
Xenopus tropicalis	6328	Xenbase:XB-GENE-978019

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 7, 2025