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tumor suppressor candidate 3

Summary

Gene Symbol

TUSC3

Aliases

MGC13453
MRT7
MagT2
Magnesium uptake/transporter TUSC3
N33
OST3A
SLC58A2
oligosaccharyltransferase 3 homolog A (S. cerevisiae)

Organism

Homo sapiens (human)

External Links

NCBI Gene

7991

HGNC

30242

KEGG Gene ID

hsa:7991

PubChem

7991

Alliance of Genome Resources

HGNC:30242

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Endoplasmic reticulum
Intellectual disability
Magnesium
Reference proteome
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13454	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 Magnesium uptake/transporter TUSC3 Protein N33

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
transmembrane transport
protein N-linked glycosylation		18455129
protein N-linked glycosylation via asparagine	IBA IMP	26864433
magnesium ion transmembrane transport	IEA
magnesium ion transport	IMP	19717468

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular process [inference]

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

magnesium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

magnesium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

magnesium ion transport

magnesium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

magnesium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

magnesium ion transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

magnesium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

magnesium ion transmembrane transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane
oligosaccharyltransferase complex	IBA IDA	15835887
plasma membrane	NAS	19717468
mitochondrion	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

oligosaccharyltransferase complex

endoplasmic reticulum protein-containing complex [inference]

oligosaccharyltransferase complex

catalytic complex [inference]

transferase complex [inference]

oligosaccharyltransferase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
magnesium ion transmembrane transporter activity	IMP TAS	19717468

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

magnesium ion transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

magnesium ion transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000104723

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K19478

Name

dolichyl-diphosphooligosaccharide---protein glycosyltransferase subunit MAGT1/TUSC3

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05976	2.4.99.18	G72079JG	G57930PW

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:12139	dysthymic disorder	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060308	autosomal recessive intellectual developmental disorder	DisGeNET
DOID:0060810	syndromic X-linked intellectual disability type 10	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0081183	autosomal recessive intellectual developmental disorder 7	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0110892	inflammatory bowel disease 1	DisGeNET

The Human Phenotype Ontology

Displaying **all 6** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0010864	Intellectual disability, severe
HP:0011463	Childhood onset

Displaying 1 entry
Disease ID	Disease Name
OMIM:611093	intellectual disability, autosomal recessive 7

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 7

OMIM Phenotypes

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 7; MRT7

KEGG Diseases

Autosomal recessive intellectual developmental disorder

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	176089	WB:WBGene00022793
Drosophila melanogaster	34137	FB:FBgn0032015
Ciona intestinalis	100184901		CIOIN14117
Callorhinchus milii	103178227		CALMI14952
Latimeria chalumnae	102347982		LATCH10681
Danio rerio	553582	ZFIN:ZDB-GENE-050522-381	DANRE17831
Salmo salar	106602198		SALSA138286
Salmo salar	123742415		SALSA138286
Gadus morhua	115540183		GADMO41607
Oryzias latipes	101168184		ORYLA00816

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements