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dehydrodolichyl diphosphate synthase subunit

Summary

Gene Symbol

DHDDS

Aliases

DS
FLJ13102
HDS
RP59
hCIT

Organism

Homo sapiens (human)

External Links

NCBI Gene

79947

HGNC

20603

KEGG Gene ID

hsa:79947

PubChem

79947

Alliance of Genome Resources

HGNC:20603

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Endoplasmic reticulum
Epilepsy
Intellectual disability
Lipid metabolism
Magnesium
Membrane
Metal-binding
Reference proteome
Retinitis pigmentosa
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86SQ9	Cis-isoprenyltransferase Cis-prenyltransferase subunit hCIT Epididymis tissue protein Li 189m

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
polyprenol biosynthetic process	IBA
dolichyl diphosphate biosynthetic process	IDA	28842490 32817466

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	NAS	32817466
dehydrodolichyl diphosphate synthase complex	IBA IDA IPI	28842490 32817466

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

dehydrodolichyl diphosphate synthase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
dehydrodolichyl diphosphate synthase activity	IDA	28842490
metal ion binding	IEA
protein binding	IPI	15110773 32817466
polyprenyltransferase activity	IDA	25066056

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000117682

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K11778

Name

ditrans,polycis-polyprenyl diphosphate synthase [EC:2.5.1.87]

References

Rhea

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate

diphosphate

Enzyme

2.5.1.87

PMID

Disease

Disease Ontology

Displaying entries **181 - 186** of **186** in total

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DO ID	Disease Name	Source
DOID:9452	steatotic liver disease	DisGeNET
DOID:9460	uterine corpus cancer	DisGeNET
DOID:9521	Laron syndrome	DisGeNET
DOID:9538	multiple myeloma	DisGeNET
DOID:9854	lingual-facial-buccal dyskinesia	DisGeNET
DOID:9993	hypoglycemia	DisGeNET

The Human Phenotype Ontology

Displaying entries **21 - 30** of 95 in total

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HPO ID	HPO Term
HP:0000563	Keratoconus
HP:0000602	Ophthalmoplegia
HP:0000613	Photophobia
HP:0000618	Blindness
HP:0000639	Nystagmus
HP:0000648	Optic atrophy
HP:0000662	Nyctalopia
HP:0000668	Hypodontia
HP:0000708	Atypical behavior
HP:0000717	Autism

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:617836	developmental delay and seizures with or without movement abnormalities
ORPHA:442835	developmental and epileptic encephalopathy, 58 developmental delay and seizures with or without movement abnormalities intellectual disability, X-linked, syndromic, Houge type intellectual disability, autosomal dominant 55, with seizures intellectual disability, autosomal dominant 56 undetermined early-onset epileptic encephalopathy
ORPHA:791	Leber congenital amaurosis 14 Leber congenital amaurosis 4 retinitis pigmentosa
OMIM:613861	retinitis pigmentosa 59

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	266904	WB:WBGene00044025
Drosophila melanogaster	31708	FB:FBgn0029980
Callorhinchus milii	103179564		CALMI18186
Latimeria chalumnae	102361662		LATCH16991
Danio rerio	406468	ZFIN:ZDB-GENE-040426-2236	DANRE10769
Astyanax mexicanus	103040074		ASTMX17827
Ictalurus punctatus	108256361		ICTPU18517
Salmo salar	106605152		SALSA125978
Salmo trutta	115177113		SALTR84858
Salmo trutta	115177121		SALTR45329

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024