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cytoplasmic polyadenylation element binding protein 4

Summary

Gene Symbol

CPEB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

80315

PubChem

80315

Alliance of Genome Resources

HGNC:21747

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Cytoplasm
Endoplasmic reticulum
Metal-binding
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Synapse
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7ZLQ8
Q17RY0
E5RFP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
response to ischemia	ISS
translation	IEA
negative regulation of cytoplasmic translation	IBA
ionotropic glutamate receptor signaling pathway	ISS
negative regulation of neuron apoptotic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

response to stimulus [inference]

response to stress [inference]

response to ischemia

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

cellular response to decreased oxygen levels

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to oxygen-containing compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
postsynaptic density	ISS
neuron projection	IBA
dendrite	ISS
dendritic spine	IEA
messenger ribonucleoprotein complex

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

messenger ribonucleoprotein complex

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

perinuclear region of cytoplasm

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21336257
translation factor activity, RNA binding	IBA
ribosome binding	IBA
mRNA 3'-UTR binding	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding [inference]

mRNA 3'-UTR binding

translation regulator activity, nucleic acid binding [inference]

translation regulator activity [inference]

translation repressor activity [inference]

mRNA regulatory element binding translation repressor activity

translation regulator activity, nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytoplasmic polyadenylation element-binding protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 5** entries
Gene Ontology
mRNA 3'-UTR binding
mRNA regulatory element binding translation repressor activity
negative regulation of cytoplasmic translation
translation factor activity, RNA binding
translation regulator activity

Displaying **all 6** entries
InterPro
CEBP, ZZ domain superfamily
Cytoplasmic polyadenylation element-binding protein, ZZ domain
Cytoplasmic polyadenylation element-binding protein
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10762	portal hypertension	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **108** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39018		FB:FBgn0264307
Mus musculus	67579		MGI:1914829	MOUSE03776
Caenorhabditis elegans	176310		WB:WBGene00000770
Rattus norvegicus	303010		RGD:1311931	RATNO01916
Danio rerio	393956		ZFIN:ZDB-GENE-040426-1557
Pan troglodytes	462277	9598_0:001701		PANTR36859
Canis lupus familiaris	479287			CANLF14803
Bos taurus	538794			BOVIN15757
Macaca mulatta	704141			MACMU38136
Monodelphis domestica	100026759			MONDO02348

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements