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Submissions

solute carrier family 38 member 1

Summary

Gene Symbol

SLC38A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

81539

PubChem

81539

Alliance of Genome Resources

HGNC:13447

Annotation

Keyword

Amino-acid transport
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H2H9	Amino acid transporter A1 N-system amino acid transporter 2 Solute carrier family 38 member 1 System A amino acid transporter 1 System N amino acid transporter 1
F8VX04

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
amino acid transmembrane transport	IBA
glycine transport	IEA
alanine transport	IEA
neurotransmitter uptake	TAS
gamma-aminobutyric acid biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process [inference]

gamma-aminobutyric acid biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

gamma-aminobutyric acid biosynthetic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

neurotransmitter transport [inference]

neurotransmitter uptake

vascular transport [inference]

transport across blood-brain barrier

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

amino acid import

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

amino acid import

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

nitrogen compound transport [inference]

amino acid transport

amino acid transmembrane transport

L-alpha-amino acid transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

amino acid import

import into cell [inference]

neurotransmitter uptake

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of glutamine transport [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of glutamine transport [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of glutamine transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamine import across plasma membrane [inference]

positive regulation of L-glutamine import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamine import across plasma membrane

regulation of biological quality [inference]

regulation of synaptic plasticity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	NAS	10891391
neuronal cell body	ISS
plasma membrane	IBA IDA ISS TAS	23137377
external side of apical plasma membrane	ISS
axon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
proline:sodium symporter activity	ISS
protein binding	IPI	25416956 32296183
glycine:sodium symporter activity	ISS
neutral L-amino acid:sodium symporter activity	ISS
amino acid:sodium symporter activity	ISS NAS	10891391

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

alanine transmembrane transporter activity [inference]

alanine:sodium symporter activity

L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

alanine transmembrane transporter activity [inference]

alanine:sodium symporter activity

L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

glycine transmembrane transporter activity [inference]

glycine:sodium symporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

organic acid:sodium symporter activity [inference]

amino acid:sodium symporter activity

neutral L-amino acid:sodium symporter activity

glycine:sodium symporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amino acid transporter

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Amino acid transporter, transmembrane domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	105727		MGI:2145895	MOUSE16050
Rattus norvegicus	170567		RGD:69645	RATNO38461
Pan troglodytes	451850	9598_0:003431		PANTR06062
Canis lupus familiaris	477633			CANLF10895
Bos taurus	527491			BOVIN29355
Macaca mulatta	702135			MACMU03624
Equus caballus	100050256			HORSE36598
Sus scrofa	100154364			PIGXX26544
Pongo abelii	100174062	9601_0:00326e		PONAB05315
Taeniopygia guttata	100228029			TAEGU08651

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements