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MIRAGE
calpain 1
Summary
- Gene Symbol
-
- CAPN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Cytoplasm
- Disease variant
- Hereditary spastic paraplegia
- Metal-binding
- Phosphoprotein
- Reference proteome
- Repeat
- Thiol protease
- Proteins
| UniProt | Protein Name |
|---|---|
| B4DWH5 |
|
| B2RDI5 |
|
| P07384 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| NMDA selective glutamate receptor signaling pathway |
|
|
| regulation of NMDA receptor activity |
|
|
| regulation of catalytic activity | ||
| receptor catabolic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| calcium-dependent cysteine-type endopeptidase activity | ||
| peptidase activity | ||
| calcium ion binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- calpain
- Functional Category
-
- K: Transcription
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
| Gene Ontology |
|---|
| calcium-dependent cysteine-type endopeptidase activity |
| hydrolase activity |
| proteolysis |
| InterPro |
|---|
| Papain-like cysteine peptidase superfamily |
| Peptidase C2, calpain family |
| Peptidase C2, calpain, catalytic domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0081292 | traumatic brain injury | |
| DOID:0110821 | hereditary spastic paraplegia 76 | |
| DOID:10230 | aortic atherosclerosis | |
| DOID:10652 | Alzheimer's disease | |
| DOID:11446 | sciatic neuropathy | |
| DOID:11723 | Duchenne muscular dystrophy | |
| DOID:1826 | epilepsy | |
| DOID:2476 | hereditary spastic paraplegia | |
| DOID:3021 | acute kidney failure |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12333 | MGI:88263 | MOUSE26972 | ||
| 29153 | RGD:2267 | |||
| 39165 | FB:FBgn0025866 | |||
| 173089 | WB:WBGene00000544 | |||
| 175326 | WB:WBGene00000545 | |||
| 176122 | WB:WBGene00000542 | |||
| 176953 | WB:WBGene00000547 | |||
| 190738 | WB:WBGene00000546 | |||
| 281661 | BOVIN23443 | |||
| 380177 | Xenbase:XB-GENE-6540652 |
