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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
acyl-CoA oxidase 2
Summary
- Gene Symbol
-
- ACOX2
- Aliases
-
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
- BRCACOX
- BRCOX
- THCCox
- branched chain acyl-CoA oxidase
- trihydroxycoprostanoyl-CoA oxidase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Direct protein sequencing
- Disease variant
- FAD
- Fatty acid metabolism
- Oxidoreductase
- Peroxisome
- Phosphoprotein
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99424 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| fatty acid beta-oxidation using acyl-CoA oxidase | ||
| very long-chain fatty acid metabolic process | ||
| bile acid biosynthetic process | ||
| lipid homeostasis |
GO Hierarchy
biological process
metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| intracellular membrane-bounded organelle | ||
| cytosol | ||
| peroxisome | ||
| peroxisomal matrix |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| flavin adenine dinucleotide binding | ||
| 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity | ||
| protein homodimerization activity | ||
| fatty acid binding | ||
| protein binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080476 | peroxisome biogenesis disorder 1A | |
| DOID:0111067 | congenital bile acid synthesis defect 6 | |
| DOID:10602 | obsolete steatorrhea | |
| DOID:114 | heart disease | |
| DOID:1287 | cardiovascular system disease | |
| DOID:1612 | breast cancer | |
| DOID:3459 | breast carcinoma | |
| DOID:3571 | liver cancer | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:687 | hepatoblastoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000511 | Vertical supranuclear gaze palsy |
| HP:0000750 | Delayed speech and language development |
| HP:0001251 | Ataxia |
| HP:0001256 | Intellectual disability, mild |
| HP:0001263 | Global developmental delay |
| HP:0001310 | Dysmetria |
| HP:0001350 | Slurred speech |
| HP:0002066 | Gait ataxia |
| HP:0002570 | Steatorrhea |
| Disease ID | Disease Name |
|---|---|
| OMIM:617308 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000966
- Gene Name
- acyl-CoA oxidase 2, branched chain
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101969528 | ICTTR03608 | ||
| 101607493 | JACJA20994 | ||
| 102428739 | MYOLU13520 | ||
| 117036966 | RHIFE16116 | ||
| 100228411 | TAEGU03814 | ||
| 101820029 | FICAL03976 | ||
| 103227815 | CHLSB10477 | ||
| 108543617 | RHIBE05449 | ||
| 104660198 | RHIRO17490 | ||
| 100579193 | NOMLE29915 |
