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glyceronephosphate O-acyltransferase

Summary

Gene Symbol

GNPAT

Aliases

DAP-AT
DAPAT
DHAPAT
dihydroxyacetone phosphate acyltransferase
glycerone-phosphate O-acyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

8443

HGNC

4416

KEGG Gene ID

hsa:8443

PubChem

8443

Alliance of Genome Resources

HGNC:4416

Annotation

Keyword

Acetylation
Acyltransferase
Alternative splicing
Cataract
Direct protein sequencing
Disease variant
Dwarfism
Membrane
Peroxisome
Phosphoprotein
Reference proteome
Rhizomelic chondrodysplasia punctata

Proteins

Displaying 1 entry
UniProt	Protein Name
O15228	Acyl-CoA:dihydroxyacetonephosphateacyltransferase Glycerone-phosphate O-acyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
synapse assembly	IEA
fatty acid metabolic process	IBA
membrane organization	IEA
triglyceride biosynthetic process	IBA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse organization [inference]

synapse assembly

membrane organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cerebellum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

response to stimulus [inference]

response to stress [inference]

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to fatty acid

response to oxygen-containing compound [inference]

response to fatty acid

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytosol
mitochondrial membrane	IBA
membrane	HDA	19946888
peroxisome	IDA NAS	15687349 9459311
peroxisomal membrane	HDA IBA TAS	21525035

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

mitochondrial membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycerol-3-phosphate O-acyltransferase activity	IBA
glycerone-phosphate O-acyltransferase activity	IBA IDA TAS	10395968 11152660 15687349 8186247 9536089

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

glycerol-3-phosphate O-acyltransferase activity

O-acetyltransferase activity [inference]

glycerone-phosphate O-acyltransferase activity

acetyltransferase activity [inference]

O-acetyltransferase activity [inference]

glycerone-phosphate O-acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

dihydroxyacetone phosphate + an acyl-CoA

CoA + a 1-acylglycerone 3-phosphate

Enzyme

2.3.1.42

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 45 in total

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DO ID	Disease Name	Source
DOID:0060249	scoliosis	DisGeNET
DOID:0060292	X-linked chondrodysplasia punctata 1	DisGeNET DisGeNET
DOID:0060293	autosomal dominant chondrodysplasia punctata	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0080352	X-linked chondrodysplasia punctata 2	DisGeNET
DOID:0080476	peroxisome biogenesis disorder 1A	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 36 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000176	Submucous cleft hard palate
HP:0000218	High palate
HP:0000239	Large fontanelles
HP:0000252	Microcephaly
HP:0000347	Micrognathia
HP:0000348	High forehead
HP:0000431	Wide nasal bridge
HP:0000463	Anteverted nares

Displaying 1 entry
Disease ID	Disease Name
OMIM:222765	rhizomelic chondrodysplasia punctata type 2

PubChem Disease

GHR Health Conditions

Rhizomelic chondrodysplasia punctata

MedGen Diseases

Rhizomelic chondrodysplasia punctata type 2

OMIM Phenotypes

RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 2; RCDP2

KEGG Diseases

Rhizomelic chondrodysplasia punctata

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001078
Gene Name: glyceronephosphate O-acyltransferase

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	174916	WB:WBGene00012911
Drosophila melanogaster	53586	FB:FBgn0040212
Callorhinchus milii	103180557		CALMI00152
Danio rerio	336430	ZFIN:ZDB-GENE-030131-8374
Danio rerio	572335	ZFIN:ZDB-GENE-040618-4
Astyanax mexicanus	103026328		ASTMX14080
Salmo trutta	115174808		SALTR54376
Gadus morhua	115534376		GADMO32084
Oryzias latipes	101155817		ORYLA11844
Oreochromis niloticus	100701045		ORENI18775

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Last updated: August 19, 2024