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translation initiation factor eIF2B subunit delta

Summary

Gene Symbol

GCD2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852974

PubChem

852974

Alliance of Genome Resources

SGD:S000003315

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Initiation factor
Phosphoprotein
Reference proteome
Repressor
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P12754	GCD complex subunit GCD2 Guanine nucleotide exchange factor subunit GCD2 eIF2B GDP-GTP exchange factor subunit delta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
translational initiation	IEA
translation	IEA
cytoplasmic translational initiation
regulation of translation	IEA
regulation of translational initiation	IDA IGI IMP IPI	8164676 8506384 8887689 9032257

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 2B complex	IDA IGI IPI	8336705 8506384
guanyl-nucleotide exchange factor complex	IDA IGI	8336705 8506384
cytosol	HDA IEA	26928762
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2B complex

intracellular protein-containing complex [inference]

guanyl-nucleotide exchange factor complex

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
enzyme regulator activity	IDA IGI IMP	8164676 8887689 9032257
translation initiation factor activity	IEA IGI IMP	2038326 8336705
guanyl-nucleotide exchange factor activity	IDA	8506384

GO Hierarchy

molecular function

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular function regulator activity [inference]

enzyme regulator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

initiation factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
cellular metabolic process

Displaying **all 3** entries
InterPro
Initiation factor 2B-like, C-terminal
Initiation factor 2B-related
NagB/RpiA transferase-like

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
eukaryotic translation initiation factor 2B complex	PMID:8506384
cytosol	PMID:26928762
guanyl-nucleotide exchange factor complex	PMID:8506384

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060868	leukoencephalopathy with vanishing white matter	Alliance of Genome Resources
DOID:0070371	leukoencephalopathy with vanishing white matter 4	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	8890		HGNC:3260
Mus musculus	13667		MGI:95300
Drosophila melanogaster	37706		FB:FBgn0034858
Rattus norvegicus	117019		RGD:620208
Caenorhabditis elegans	179331		WB:WBGene00008670
Danio rerio	541548		ZFIN:ZDB-GENE-030131-955
Xenopus tropicalis	779817		Xenbase:XB-GENE-997731
Kluyveromyces lactis	2895791	28985_0:0011f9
Eremothecium gossypii ATCC 10895	4620708	284811_0:000a4b
Vanderwaltozyma polyspora DSM 70294	5542567	436907_0:00010c

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements