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malate dehydrogenase MDH2

Summary

Gene Symbol

MDH2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853994

KEGG Gene ID

sce:YOL126C

PubChem

853994

Alliance of Genome Resources

SGD:S000005486

Annotation

Keyword

Cytoplasm
Direct protein sequencing
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P22133

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
malate metabolic process	IEA
protein import into peroxisome matrix	IMP	19118449
tricarboxylic acid cycle	IEA
gluconeogenesis	IMP	12730240

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

malate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

tricarboxylic acid cycle

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

malate metabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

malate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

malate metabolic process

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization [inference]

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome matrix

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

intracellular protein transmembrane transport [inference]

protein import into peroxisome matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into peroxisome matrix

establishment of protein localization to peroxisome [inference]

protein import into peroxisome matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	IBA IDA	1986231
cytoplasm	HDA IBA IEA	11914276
nuclear periphery	IDA	25817432
mitochondrion

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
L-malate dehydrogenase activity	IBA IDA IEA IMP	1986231

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

L-malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

L-malate dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00026

Name

malate dehydrogenase [EC:1.1.1.37]

References

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
cytoplasm	PMID:11914276
nuclear periphery	PMID:25817432
cytosol	PMID:1986231

Rhea

(S)-malate + NAD⁺

H⁺ + oxaloacetate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080433	developmental and epileptic encephalopathy 51	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175936	WB:WBGene00003162
Drosophila melanogaster	39469	FB:FBgn0036327
Drosophila melanogaster	42185	FB:FBgn0262559
Danio rerio	406405	ZFIN:ZDB-GENE-040426-2143
Xenopus tropicalis	496892	Xenbase:XB-GENE-971714
Homo sapiens	4191	HGNC:6971
Mus musculus	17448	MGI:97050
Rattus norvegicus	81829	RGD:619719

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Last updated: August 19, 2024