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Guidelines

MIRAGE

cytochrome-b5 reductase

Summary

Gene Symbol

CBR1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854768

KEGG Gene ID

sce:YIL043C

PubChem

854768

Alliance of Genome Resources

SGD:S000001305

Annotation

Keyword

3D-structure
FAD
Mitochondrion outer membrane
NAD
Oxidoreductase
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38626	Microsomal cytochrome b reductase P35

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tRNA wobble uridine modification	IMP	27694803
protein histidyl modification to diphthamide	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

macromolecule modification [inference]

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-histidine modification [inference]

protein histidyl modification to diphthamide

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

RNA modification [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA wobble base modification [inference]

tRNA wobble uridine modification

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
nucleus	HDA	26928762
mitochondrion	IEA
mitochondrion	HDA	14576278 16823961 24769239
mitochondrial outer membrane	IEA
mitochondrial outer membrane	HDA	16407407

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytochrome-b5 reductase activity, acting on NAD(P)H	IDA	14930 27694803
cytochrome-b5 reductase activity, acting on NAD(P)H	IBA
cytochrome-b5 reductase activity, acting on NAD(P)H	IEA
oxidoreductase activity	IEA
transferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [inference]

cytochrome-b5 reductase activity, acting on NAD(P)H

transferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

reductase

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
Flavoprotein pyridine nucleotide cytochrome reductase
NADH
Oxidoreductase FAD/NAD(P)-binding
Riboflavin synthase-like beta-barrel

KEGG BRITE Database

Orthology

K00326

Name

cytochrome-b5 reductase [EC:1.6.2.2]

References

10611283

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
mitochondrial outer membrane	PMID:16407407
mitochondrion	PMID:14576278 PMID:16823961 PMID:24769239
nucleus	PMID:26928762

Rhea

NADH

H⁺ + NAD⁺

Enzyme

1.6.2.2

PMID

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	1727	ZFIN:ZDB-GENE-030131-3281
Xenopus tropicalis	51700	Xenbase:XB-GENE-1006041
Xenopus tropicalis	51706	Xenbase:XB-GENE-946788
Xenopus tropicalis	854768	Xenbase:XB-GENE-946788

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025