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Pan1p

Summary

Gene Symbol

PAN1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854822

PubChem

854822

Alliance of Genome Resources

SGD:S000001445

Annotation

Keyword

Actin-binding
Calcium
Cell membrane
Coiled coil
Cytoskeleton
Direct protein sequencing
Endocytosis
Endosome
Metal-binding
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P32521	Mitochondrial distribution of proteins protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA IEA IMP	8978817
reticulophagy	IGI	35101986
endosomal transport	IBA
positive regulation of Arp2/3 complex-mediated actin nucleation	IDA	11433303 16824951 17151356
axial cellular bud site selection	IMP	8756649

GO Hierarchy

biological process

reproduction [inference]

asexual reproduction [inference]

cell budding [inference]

reproduction of a single-celled organism [inference]

cell budding [inference]

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

reticulophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

reticulophagy

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

cellular bud site selection [inference]

vesicle-mediated transport [inference]

cell cycle process [inference]

mitotic cell cycle process [inference]

cellular bud site selection [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

reticulophagy

cell division [inference]

cell budding [inference]

cellular localization [inference]

intracellular transport [inference]

endosomal transport

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy [inference]

reticulophagy

cell wall organization or biogenesis [inference]

cell wall organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

organelle disassembly [inference]

reticulophagy

cellular component disassembly [inference]

organelle disassembly [inference]

reticulophagy

cellular component assembly [inference]

actin cortical patch assembly

actin cortical patch organization [inference]

actin cortical patch assembly

external encapsulating structure organization [inference]

cell wall organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

intracellular transport [inference]

endosomal transport

import into cell [inference]

endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mating projection tip	HDA	19053807
plasma membrane	HDA IBA IEA	11914276
cellular bud neck	HDA	26928762
endosome	IEA
actin cytoskeleton-regulatory complex	IDA IPI	10594004 17151356

GO Hierarchy

cellular component

protein-containing complex [inference]

actin cytoskeleton-regulatory complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

site of polarized growth [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

cell pole [inference]

cell tip [inference]

mating projection tip

endocytic patch [inference]

actin cortical patch

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	IEA
metal ion binding	IEA
Arp2/3 complex binding	IDA	11433303
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

intersectin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
cellular bud neck	PMID:26928762
cytoplasm	PMID:17967424
plasma membrane	PMID:11914276
actin cytoskeleton-regulatory complex	PMID:10594004 PMID:17151356
mating projection tip	PMID:19053807
actin cortical patch	PMID:14622601 PMID:16824951
nucleus	PMID:17967424

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110734	neurodegeneration with brain iron accumulation	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 33 in total

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Species	Gene ID	OrthoDB
Kluyveromyces lactis	2893445	28985_0:000922
Eremothecium gossypii ATCC 10895	4620263	284811_0:000560
Vanderwaltozyma polyspora DSM 70294	5542672	436907_0:00016e
Lachancea thermotolerans CBS 6340	8292998	559295_0:000cf3
Eremothecium cymbalariae DBVPG#7215	11470101	931890_0:000960
Naumovozyma dairenensis CBS 421	11493572	1071378_0:000037
Naumovozyma dairenensis CBS 421	11494045	1071378_0:0001ed
Torulaspora delbrueckii	11501425	4950_0:001368
Naumovozyma castellii CBS 4309	11525469	1064592_0:0014e7
Tetrapisispora phaffii CBS 4417	11532847	1071381_0:000df9