GlyCosmos Portal

Annotation

Keyword

DNA repair
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P53397

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
base-excision repair, AP site formation	IBA IDA IEA	8643552
nucleotide-excision repair	IEA
base-excision repair	IEA
DNA repair	IEA IMP	11239005
error-free translesion synthesis	IGI	19264809

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IBA IDA IEA	11239005
mitochondrion	IDA	11239005

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lyase activity	IEA
hydrolase activity, acting on glycosyl bonds	IEA
oxidized base lesion DNA N-glycosylase activity	IEA
oxidized purine nucleobase lesion DNA N-glycosylase activity	IDA	8643552
damaged DNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

lyase activity

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
mitochondrion	PMID:11239005
nucleus	PMID:11239005

Disease

Disease Ontology

Displaying entries **21 - 26** of 26 in total

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DO ID	Disease Name	Source
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources
DOID:5520	head and neck squamous cell carcinoma	Alliance of Genome Resources
DOID:678	progressive supranuclear palsy	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9669	senile cataract	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	31806	FB:FBgn0027864
Danio rerio	791194	ZFIN:ZDB-GENE-070112-932
Xenopus tropicalis	100380072	Xenbase:XB-GENE-995809
Homo sapiens	4968	HGNC:8125
Mus musculus	18294	MGI:1097693
Rattus norvegicus	81528	RGD:621168

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements