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bifunctional endoribonuclease/protein kinase IRE1

Summary

Gene Symbol

IRE1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856478

PubChem

856478

Alliance of Genome Resources

SGD:S000001121

Annotation

Keyword

3D-structure
ATP-binding
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Signal
Transcription regulation
Transmembrane helix
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
P32361	Endoplasmic reticulum-to-nucleus signaling 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
protein localization to Golgi apparatus	IMP	26966233
IRE1-mediated unfolded protein response	IBA
response to unfolded protein	IEA
protein phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cell wall organization or biogenesis [inference]

cell wall organization [inference]

fungal-type cell wall organization

fungal-type cell wall organization or biogenesis [inference]

fungal-type cell wall organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

external encapsulating structure organization [inference]

cell wall organization [inference]

fungal-type cell wall organization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

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GO Term	Evidence Code	PMID
membrane	IEA
endoplasmic reticulum membrane	IDA IEA	8358794
IRE1-TRAF2-ASK1 complex	IBA
Ire1 complex
endoplasmic reticulum	HDA IEA	26928762

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

Ire1 complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

Ire1 complex

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

Ire1 complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
protein serine kinase activity	IEA
hydrolase activity	IEA
metal ion binding	IEA
protein serine/threonine kinase activity	IBA IDA IEA	8663458
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
IRE1-mediated unfolded protein response
RNA endonuclease activity
RNA nuclease activity
endoplasmic reticulum unfolded protein response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
kinase activity
mRNA processing
nucleotide binding
phosphorylation

Displaying **all 8** entries
InterPro
KEN domain superfamily
KEN domain
Protein kinase domain
Protein kinase-like domain superfamily
Quinoprotein alcohol dehydrogenase-like superfamily
Serine/threonine-protein kinase, active site
Serine/threonine-protein kinase/endoribonuclease IRE1/2-like
WD40/YVTN repeat-like-containing domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nucleus	PMID:17035634
endoplasmic reticulum membrane	PMID:8358794
endoplasmic reticulum	PMID:26928762

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:8557	oropharynx cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	2081	HGNC:3449
Homo sapiens	10595	HGNC:16942
Mus musculus	26918	MGI:1349436
Drosophila melanogaster	42358	FB:FBgn0261984
Mus musculus	78943	MGI:1930134
Caenorhabditis elegans	174305	WB:WBGene00002147
Rattus norvegicus	365363	RGD:1308743
Rattus norvegicus	498013	RGD:1559716
Danio rerio	553551	ZFIN:ZDB-GENE-050522-431
Danio rerio	567021	ZFIN:ZDB-GENE-090312-15

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements