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Serine/threonine-protein kinase/endoribonuclease IRE1

Summary

UniProt ID

P32361

Gene Symbol

IRE1
ERN1

Organism

Saccharomyces cerevisiae S288C

External Links

PubChem: P32361

Annotation

Keyword

3D-structure
ATP-binding
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Signal
Transcription regulation
Transmembrane helix
Unfolded protein response

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
endoplasmic reticulum unfolded protein response
response to endoplasmic reticulum stress
inositol metabolic process
protein localization to Golgi apparatus
IRE1-mediated unfolded protein response
mRNA processing
fungal-type cell wall organization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Displaying **all 5** entries
GO Term
endoplasmic reticulum
endoplasmic reticulum membrane
nucleus
Ire1 complex
IRE1-TRAF2-ASK1 complex

Displaying **all 8** entries
GO Term
protein kinase activity
protein serine/threonine kinase activity
ATP binding
identical protein binding
protein serine kinase activity
RNA endonuclease activity
metal ion binding
unfolded protein binding

Annotation information from UniProt.

Sequence

MRLLRRNMLVLTLLVCVFSSIISCSIPLSSRTSRRQIVEDEVASTKKLNFNYGVDKNINSPIPAPRTTEGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISVPYLENRSLNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGNIYYFNAHQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPGSKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIHSYDGASYNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLRTNENILVPHPFNPGDHESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNSLKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFKILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEKDNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
111	N-linked (GlcNAc...) asparagine	UniProt
213	N-linked (GlcNAc...) asparagine	UniProt
298	N-linked (GlcNAc...) asparagine	UniProt
397	N-linked (GlcNAc...) asparagine	UniProt