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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
insulin receptor substrate 2
Summary
- Gene Symbol
-
- IRS2
- Organism
- Homo sapiens (human)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| positive regulation of fatty acid beta-oxidation | ||
| response to glucose | ||
| positive regulation of mesenchymal cell proliferation | ||
| positive regulation of insulin secretion |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| phosphatidylinositol 3-kinase binding | ||
| phosphatidylinositol 3-kinase activator activity | ||
| protein phosphatase binding | ||
| protein domain specific binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Insulin receptor substrate
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:1059 | intellectual disability | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10914 | amnestic disorder | |
| DOID:11476 | osteoporosis | |
| DOID:4194 | glucose metabolism disease | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 29376 | RGD:69316 | RATNO11147 | ||
| 64880 | FB:FBgn0024248 | |||
| 384783 | MGI:109334 | MOUSE59719 | ||
| 393285 | ZFIN:ZDB-GENE-040426-975 | |||
| 452657 | 9598_0:0039a5 | PANTR08073 | ||
| 572001 | ZFIN:ZDB-GENE-081104-462 | DANRE44329 | ||
| 698536 | MACMU16286 | |||
| 100023831 | MONDO32450 | |||
| 100146249 | HORSE12355 | |||
| 100220894 | TAEGU11482 |
