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serpin family H member 1

Summary

Gene Symbol

SERPINH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

871

PubChem

871

Alliance of Genome Resources

HGNC:1546

Annotation

Keyword

Acetylation
Chaperone
Collagen
Endoplasmic reticulum
Glycoprotein
Osteogenesis imperfecta
Phosphoprotein
Reference proteome
Signal
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K259	Collagen-binding protein
P50454	47 kDa heat shock protein Arsenic-transactivated protein 3 Cell proliferation-inducing gene 14 protein Collagen-binding protein Rheumatoid arthritis-related antigen RA-A47

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
protein maturation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	25037231 28327460 28675934
endoplasmic reticulum lumen	TAS
membrane raft	IDA	25204797
endoplasmic reticulum	IBA IDA NAS	7656593
endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

membrane microdomain [inference]

membrane raft

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32814053
serine-type endopeptidase inhibitor activity	IBA
collagen binding	NAS	7656593
RNA binding	HDA	22658674
unfolded protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

unfolded protein binding

protein-containing complex binding [inference]

collagen binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110346	osteogenesis imperfecta type 10	Alliance of Genome Resources
DOID:0111144	preterm premature rupture of the membranes	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12406		MGI:88283	MOUSE54981
Rattus norvegicus	29345		RGD:69302	RATNO16122
Danio rerio	30449		ZFIN:ZDB-GENE-990415-93	DANRE08302
Drosophila melanogaster	40235		FB:FBgn0036969
Drosophila melanogaster	40236		FB:FBgn0036970
Drosophila melanogaster	41221		FB:FBgn0037772
Xenopus laevis	379951		Xenbase:XB-GENE-17337487
Sus scrofa	396773			PIGXX35012
Pan troglodytes	466899	9598_0:0033bc		PANTR03863
Canis lupus familiaris	485187			CANLF08258