GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Inflammatory response
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95256	Accessory protein-like CD218 antigen-like family member B CDw218b IL-1R accessory protein-like Interleukin-1 receptor 7 Interleukin-18 receptor accessory protein-like Interleukin-18 receptor beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IBA
inflammatory response	IEA
immune response	TAS	9792649
cell population proliferation	IEA
interleukin-18-mediated signaling pathway	IDA	25500532

GO Hierarchy

biological process

immune system process [inference]

immune response

adaptive immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-18-mediated signaling pathway

cell population proliferation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

immune response

adaptive immune response

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of innate immune response [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-18-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IC	25500532
plasma membrane	IBA
cell surface	IBA
interleukin-18 receptor complex	IDA	25500532

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-18 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-18 receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
NAD+ nucleosidase activity
protein binding	IPI	32814053
coreceptor activity	IDA	25500532
interleukin-18 receptor activity	IDA	25500532
interleukin-18 receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interleukin-18 receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-18 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fibroblast growth factor receptor

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Rhea

RHEA:16301

H₂O + NAD⁺

H⁺ + nicotinamide + ADP-D-ribose

Enzyme

PMID

Ortholog

Displaying entries **41 - 50** of 60 in total

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Species	Gene ID	Orthologous MAtrix
Takifugu rubripes	105417274	TAKRU08790
Macaca nemestrina	105490128	MACNE13399
Mandrillus leucophaeus	105531613	MANLE02024
Cercocebus atys	105583641	CERAT23744
Aotus nancymaae	105730373	AOTNA30252
Dipodomys ordii	105988155	DIPOR11981
Salmo salar	106575893	SALSA51036
Equus asinus asinus	106839405	EQUAS24319
Rhinopithecus bieti	108524104	RHIBE22879
Phascolarctos cinereus	110209400	PHACI21504

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements