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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
methyl-CpG binding domain 4, DNA glycosylase
Summary
- Gene Symbol
-
- MBD4
- Aliases
-
- MED1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- DNA repair
- DNA-binding
- Disease variant
- Hydrolase
- Nucleus
- Phosphoprotein
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| O95243 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| depyrimidination | ||
| DNA repair | ||
| response to estradiol |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nuclear speck | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding | ||
| DNA N-glycosylase activity | ||
| satellite DNA binding | ||
| pyrimidine-specific mismatch base pair DNA N-glycosylase activity | ||
| DNA endonuclease activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0080195 | Marinesco-Sjogren syndrome | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:1019 | osteomyelitis | |
| DOID:10534 | stomach cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11266 | Hantavirus hemorrhagic fever with renal syndrome | |
| DOID:11661 | blue color blindness | |
| DOID:12849 | autistic disorder | |
| DOID:1324 | lung cancer |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002858 | Meningioma |
| HP:0003003 | Colon cancer |
| HP:0003581 | Adult onset |
| HP:0003596 | Middle age onset |
| HP:0003621 | Juvenile onset |
| HP:0004808 | Acute myeloid leukemia |
| HP:0005227 | Adenomatous colonic polyposis |
| HP:0007716 | Uveal melanoma |
| HP:0011462 | Young adult onset |
| Disease ID | Disease Name |
|---|---|
| OMIM:619975 |
|
| OMIM:606660 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101887128 | ZFIN:ZDB-GENE-040213-1 | ||
| 108714643 | Xenbase:XB-GENE-6487015 | ||
| 733528 | Xenbase:XB-GENE-489215 | ||
| 100074449 | ORNAN28005 | ||
| 103108238 | ERIEU11017 | ||
| 105585848 | CERAT02528 | ||
| 720557 | MACMU28014 | ||
| 105477770 | MACNE19441 | ||
| 105555322 | MANLE36733 | ||
| 101134542 | GORGO28609 |
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for MBD4
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| phosphatidylinositol glycan anchor biosynthesis class P |
|
|
| phosphatidylinositol glycan anchor biosynthesis class U |
|
|
| arylsulfatase family member K |
|
|
| glucose-6-phosphatase catalytic subunit 3 |
|
|
| acylphosphatase 2 |
|
|
| phosphatidylinositol glycan anchor biosynthesis class S |
|
|
| arylsulfatase G |
|
|
| ectonucleotide pyrophosphatase/phosphodiesterase 3 |
|
|
| cathepsin A |
|
|
| FIG4 phosphoinositide 5-phosphatase |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for MBD4
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| methyl-CpG binding domain 4, DNA glycosylase |
|
