GlyCosmos Portal

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GO Term	Evidence Code	PMID
procollagen-proline 4-dioxygenase activity	IDA	9211872
procollagen-proline 4-dioxygenase activity	IBA
iron ion binding	IEA
protein binding	IPI	25416956 30021884 32814053 33961781 35271311
electron transfer activity	TAS	9211872

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prolyl 4-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 6** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase alpha-subunit, N-terminal
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11830	myopia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 88 in total

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Species	Gene ID	Orthologous MAtrix
Ailuropoda melanoleuca	100480972	AILME19131
Meleagris gallopavo	100547385	MELGA04281
Anolis carolinensis	100567447	ANOCA03237
Nomascus leucogenys	100593863	NOMLE24113
Sus scrofa	100623801	PIGXX19704
Loxodonta africana	100676749	LOXAF19935
Cavia porcellus	100718564	CAVPO20567
Cricetulus griseus	100760683	CRIGR06002
Sarcophilus harrisii	100931276	SARHA09559
Otolemur garnettii	100957889	OTOGA18554

GlyTouCan

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OrthoDB (Group)

International Collaboration

Acknowledgements