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GO Term	Evidence Code	PMID
procollagen-proline 4-dioxygenase activity	IDA	9211872
procollagen-proline 4-dioxygenase activity	IBA
iron ion binding	IEA
protein binding	IPI	25416956 30021884 32814053 33961781 35271311
electron transfer activity	TAS	9211872

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prolyl 4-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 6** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase alpha-subunit, N-terminal
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11830	myopia	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 88 in total

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Species	Gene ID	Orthologous MAtrix
Cercocebus atys	105599731	CERAT07330
Aotus nancymaae	105715743	AOTNA00602
Propithecus coquereli	105821021	PROCO29328
Dipodomys ordii	105998956	DIPOR21966
Ictalurus punctatus	108278977	ICTPU11356
Rhinopithecus bieti	108529597	RHIBE10724
Crocodylus porosus	109310077	CROPO17415
Phascolarctos cinereus	110211708	PHACI10424
Vulpes vulpes	112917089	VULVU09793
Pseudonaja textilis	113433739	PSETE03993

GlyTouCan

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OrthoDB (Group)

International Collaboration

Acknowledgements