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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
heparan sulfate 6-O-sulfotransferase 1
Summary
- Gene Symbol
-
- HS6ST1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Coiled coil
- Disease variant
- Glycoprotein
- Hypogonadotropic hypogonadism
- Kallmann syndrome
- Reference proteome
- Signal-anchor
- Transferase
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O60243 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| lung alveolus development | ||
| angiogenesis | ||
| labyrinthine layer blood vessel development | ||
| neuron development | ||
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification |
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane |
|
|
| Golgi membrane |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| heparan sulfate 6-O-sulfotransferase activity | ||
| sulfotransferase activity |
|
|
| protein binding |
GO Hierarchy
GlycoGene Database (GGDB)
- GGDB ID
- gg031
- Gene Symbol
-
- HS6ST1
- Orthologous Gene
| Species | Protein | mRNA |
|---|---|---|
| Rattus norvegicus | XP_237060 | XM_237060 |
| Drosophila melanogaster | NP_524409 | NM_079685 |
| Caenorhabditis elegans | NP_508895 | NM_076494 |
| Mus musculus | NP_056633 | NM_015818 |
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0090090 | hypogonadotropic hypogonadism 19 with or without anosmia | |
| DOID:0090092 | hypogonadotropic hypogonadism 3 with or without anosmia | |
| DOID:0090093 | hypogonadotropic hypogonadism 21 with or without anosmia | |
| DOID:0090094 | hypogonadotropic hypogonadism 1 with or without anosmia | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:10688 | hypertrophy of breast | |
| DOID:11120 | psychologic dyspareunia | |
| DOID:11383 | cryptorchidism | |
| DOID:11476 | osteoporosis | |
| DOID:11603 | infant gynecomastia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0003164 | Hypothalamic gonadotropin-releasing hormone deficiency |
| HP:0003187 | Breast hypoplasia |
| HP:0003782 | Eunuchoid habitus |
| HP:0004349 | Reduced bone mineral density |
| HP:0004409 | Hyposmia |
| HP:0005280 | Depressed nasal bridge |
| HP:0006610 | Wide intermamillary distance |
| HP:0008064 | Ichthyosis |
| HP:0008187 | Absence of secondary sex characteristics |
| HP:0008197 | Absence of pubertal development |
| Disease ID | Disease Name |
|---|---|
| ORPHA:478 |
|
| ORPHA:432 |
|
| OMIM:614880 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101693571 | MUSPF01669 | ||
| 101091388 | FELCA18152 | ||
| 122228763 | PANLE10922 | ||
| 118898074 | BALMU00047 | ||
| 100068973 | HORSE13081 | ||
| 100156717 | PIGXX09250 | ||
| 518563 | BOVIN23835 | ||
| 106502605 | CAPHI21172 | ||
| 105995165 | DIPOR17556 | ||
| 50785 | MGI:1354958 | MOUSE29233 |
