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tight junction protein 2

Summary

Gene Symbol

TJP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

9414

PubChem

9414

Alliance of Genome Resources

HGNC:11828

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Cell membrane
Disease variant
Intrahepatic cholestasis
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Tight junction

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z954
B7Z2R3
Q9UDY2	Tight junction protein 2 Zona occludens protein 2 Zonula occludens protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
GDP metabolic process	IEA
intestinal absorption	IMP	23885123
maintenance of blood-brain barrier	NAS	30280653
positive regulation of blood-brain barrier permeability	IBA IMP	19148554

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

homotypic cell-cell adhesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

nucleoside monophosphate metabolic process [inference]

purine nucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

ribonucleoside monophosphate metabolic process [inference]

purine ribonucleoside monophosphate metabolic process [inference]

GMP metabolic process

nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

GDP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell-cell junction organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability [inference]

positive regulation of blood-brain barrier permeability

regulation of blood-brain barrier permeability [inference]

positive regulation of blood-brain barrier permeability

digestive system process [inference]

intestinal absorption

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

establishment of localization [inference]

transport [inference]

intestinal absorption

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

biological regulation [inference]

regulation of biological quality [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability [inference]

positive regulation of blood-brain barrier permeability

regulation of blood-brain barrier permeability [inference]

positive regulation of blood-brain barrier permeability

regulation of membrane permeability

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell-cell contact zone	IDA	21679692
plasma membrane	IBA IDA TAS	11090614
adherens junction	IEA
nucleoplasm	TAS
nucleus	IDA	20868367

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15975580 18823282 22665060 23885123
guanylate kinase activity	TAS	8824195
protein tyrosine kinase binding	IPI	21679692
protein-macromolecule adaptor activity	IDA	23885123
transmembrane transporter binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

nucleobase-containing compound kinase activity [inference]

nucleoside monophosphate kinase activity [inference]

guanylate kinase activity

phosphotransferase activity, phosphate group as acceptor [inference]

nucleoside monophosphate kinase activity [inference]

guanylate kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

cell adhesion molecule binding

cadherin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tight junction protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion molecule binding
cell-cell junction organization
establishment of endothelial intestinal barrier
positive regulation of blood-brain barrier permeability
protein localization to cell-cell junction

Displaying **all 7** entries
InterPro
Guanylate kinase-like domain
Guanylate kinase/L-type calcium channel beta subunit
P-loop containing nucleoside triphosphate hydrolase
PDZ domain
PDZ superfamily
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:0070224	progressive familial intrahepatic cholestasis 4	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	21873		MGI:1341872	MOUSE24897
Drosophila melanogaster	41062		FB:FBgn0262614
Rattus norvegicus	115769		RGD:619807	RATNO17457
Caenorhabditis elegans	173316		WB:WBGene00013683
Canis lupus familiaris	403854			CANLF00443
Bos taurus	407101			BOVIN34421
Danio rerio	436639		ZFIN:ZDB-GENE-040718-58
Ovis aries	443506			SHEEP09087
Pan troglodytes	464514	9598_0:0027d9		PANTR44067
Danio rerio	565446		ZFIN:ZDB-GENE-070925-2	DANRE01048

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OrthoDB (Group)

International Collaboration

Acknowledgements