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Tight junction protein ZO-2

Summary

UniProt ID

Q9UDY2

Gene Symbol

TJP2
X104
ZO2

Gene ID

9414

Organism

Homo sapiens (human)

External Links

GlyGen: Q9UDY2
PubChem: Q9UDY2
The O-GlcNAc Database: Q9UDY2
RaftProt: Q9UDY2
O-GlcNAcAtlas: Q9UDY2
Re-Glyco: Q9UDY2

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Cell membrane
Disease variant
Intrahepatic cholestasis
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Tight junction

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
cytosol
adherens junction
bicellular tight junction
cell-cell contact zone
nucleus
plasma membrane
nucleoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 9** entries
GO Term
maintenance of blood-brain barrier
cell-cell junction organization
establishment of endothelial intestinal barrier
regulation of membrane permeability
positive regulation of blood-brain barrier permeability
protein localization to cell-cell junction
homotypic cell-cell adhesion
intestinal absorption
cell-cell adhesion

Displaying **all 7** entries
GO Term
guanylate kinase activity
protein domain specific binding
protein-macromolecule adaptor activity
transmembrane transporter binding
cadherin binding
cell adhesion molecule binding
protein tyrosine kinase binding

Annotation information from UniProt.

Sequence

MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
396	G37692EO G54010QB	GlyGen
1031	G49108TO	GlyGen
1032	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Apoptotic cleavage of cell adhesion proteins	Homo sapiens
RHOA GTPase cycle	Homo sapiens
RHOB GTPase cycle	Homo sapiens
RHOC GTPase cycle	Homo sapiens
Signaling by Hippo	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	Alliance of Genome Resources
DOID:0070224	progressive familial intrahepatic cholestasis 4	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements