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hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

Summary

Gene Symbol

H6PD

Aliases

6-phosphogluconolactonase
GDH/6PGL endoplasmic bifunctional protein
H6PDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

9563

HGNC

4795

KEGG Gene ID

hsa:9563

PubChem

9563

Alliance of Genome Resources

HGNC:4795

Annotation

Keyword

3D-structure
Alternative splicing
Disease variant
Endoplasmic reticulum
Glucose metabolism
Glycoprotein
Hydrolase
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Pyrrolidone carboxylic acid
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O95479

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of cortisol biosynthetic process	IMP	18628520 23132696
pentose-phosphate shunt, oxidative branch	IBA IMP	18628520 23132696
response to nutrient levels	IEA
response to alcohol	IEA
glucose metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt, oxidative branch

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt, oxidative branch

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to chemical [inference]

response to organic substance [inference]

response to alcohol

response to oxygen-containing compound [inference]

response to alcohol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of ketone biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

regulation of glucocorticoid metabolic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

regulation of hormone biosynthetic process [inference]

regulation of steroid hormone biosynthetic process [inference]

regulation of glucocorticoid biosynthetic process [inference]

regulation of cortisol biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	18628520
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
6-phosphogluconolactonase activity	ISS
NADP binding	IEA
glucose-6-phosphate dehydrogenase activity	IBA IDA	18628520 23132696
glucose 1-dehydrogenase (NAD+) activity	IEA
glucose 1-dehydrogenase (NADP+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

glucose dehydrogenase activity [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

6-phosphogluconolactonase activity

binding [inference]

carbohydrate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucose-6-phosphate 1-dehydrogenase 1

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
NADP binding
glucose metabolic process
glucose-6-phosphate dehydrogenase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity
pentose-phosphate shunt, oxidative branch
pentose-phosphate shunt

Displaying **all 5** entries
InterPro
Glucose-6-phosphate dehydrogenase, C-terminal
Glucose-6-phosphate dehydrogenase, NAD-binding
Glucose-6-phosphate dehydrogenase, active site
Glucose-6-phosphate dehydrogenase
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000049239

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)