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cell division cycle 25A

Summary

Gene Symbol

CDC25A

Organism

Homo sapiens (human)

External Links

NCBI Gene

993

PubChem

993

Alliance of Genome Resources

HGNC:1725

Annotation

Keyword

3D-structure
Alternative splicing
Mitosis
Phosphoprotein
Protein phosphatase
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P30304	Dual specificity phosphatase Cdc25A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of G2/MI transition of meiotic cell cycle	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cell population proliferation

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cell division

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of meiotic cell cycle phase transition [inference]

regulation of G2/MI transition of meiotic cell cycle [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of G2/MI transition of meiotic cell cycle [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of reproductive process [inference]

regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

regulation of meiotic cell cycle phase transition [inference]

regulation of G2/MI transition of meiotic cell cycle [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of reproductive process [inference]

positive regulation of meiotic cell cycle [inference]

positive regulation of meiotic cell cycle phase transition [inference]

positive regulation of G2/MI transition of meiotic cell cycle

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity [inference]

regulation of cyclin-dependent protein serine/threonine kinase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleus	IBA
cytosol	TAS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11298456 15161933 19289404 28330616 32296183 35271311 7644510
protein tyrosine phosphatase activity	IBA IDA	20360007
protein-folding chaperone binding	IPI	22843495
phosphoprotein phosphatase activity	IDA TAS	20360007
protein kinase binding	IPI	21376736

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein-folding chaperone binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

m-phase inducer phosphatase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
G2/M transition of mitotic cell cycle
cell cycle
cell division
hydrolase activity
phosphoprotein phosphatase activity
positive regulation of G2/MI transition of meiotic cell cycle
positive regulation of cell cycle G2/M phase transition
protein tyrosine phosphatase activity

Displaying **all 3** entries
InterPro
M-phase inducer phosphatase
Rhodanese-like domain superfamily
Rhodanese-like domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0110861	autosomal recessive polycystic kidney disease	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:2101	vulva squamous cell carcinoma	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 63 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Bos taurus	520188			BOVIN17911
Macaca mulatta	710858			MACMU29100
Xenopus tropicalis	733851		Xenbase:XB-GENE-5809292
Xenopus laevis	734734		Xenbase:XB-GENE-5809427
Saccharomyces cerevisiae S288C	855052		SGD:S000004639
Monodelphis domestica	100018150			MONDO28928
Equus caballus	100064223			HORSE12175
Taeniopygia guttata	100231363			TAEGU18039
Oryctolagus cuniculus	100354280			RABIT12791
Callithrix jacchus	100408832			CALJA12367

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Last updated: December 9, 2024