RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
6s:n-acetyl
7s:sulfate
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(3+2)5d
5:5d(5+1)6n
6:4o(6+1)7n

• Seko Y et al. Expression of sialyl Lewis(X) in rat heart with ischaemia/reperfusion and reduction of myocardial reperfusion injury by a monoclonal antibody against sialyl Lewis(X) J Pathol. 1996 Nov;180:(3):305-10. doi: 10.1002/(SICI)1096-9896(199611)180:3<305::AID-PATH651>3.0.CO;2-S. PMID: 8958810.

• Fieger CB et al. Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J Biol Chem. 2003 Jul 25;278:(30):27390-8. doi: 10.1074/jbc.M304204200. PMID: 12889478.

• Hemmerich S et al. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity. 2001 Aug;15:(2):237-47. doi: 10.1016/s1074-7613(01)00188-1. PMID: 11520459.

• Tu L et al. L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. J Immunol. 1999 Nov 1;163:(9):5070-8. PMID: 10528213.

• Clark RA et al. L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. J Cell Biol. 1998 Feb 9;140:(3):721-31. doi: 10.1083/jcb.140.3.721. PMID: 9456330.

• Hemmerich S et al. Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J Biol Chem. 1995 May 19;270:(20):12035-47. doi: 10.1074/jbc.270.20.12035. PMID: 7538131.

• Uchimura K et al. Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem. 1998 Aug 28;273:(35):22577-83. doi: 10.1074/jbc.273.35.22577. PMID: 9712885.

• Sawada M et al. Specific expression of a complex sialyl Lewis X antigen on high endothelial venules of human lymph nodes: possible candidate for L-selectin ligand. Biochem Biophys Res Commun. 1993 May 28;193:(1):337-47. doi: 10.1006/bbrc.1993.1629. PMID: 7684905.

• Zhang K et al. Novel monoclonal antibodies to putative selectin carbohydrate ligands that inhibit selectin binding to myeloid cells. Hybridoma. 1998 Oct;17:(5):445-56. doi: 10.1089/hyb.1998.17.445. PMID: 9873990.

• Renkonen J et al. Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites. Am J Pathol. 2002 Aug;161:(2):543-50. doi: 10.1016/S0002-9440(10)64210-1. PMID: 12163379.

• Uchimura K et al. N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J Biol Chem. 2004 Aug 13;279:(33):35001-8. doi: 10.1074/jbc.M404456200. PMID: 15175329.

• Tamatani T et al. Recognition of consensus CHO structure in ligands for selectins by novel antibody against sialyl Lewis X. Am J Physiol. 1995 Oct;269:(4 Pt 2):H1282-7. doi: 10.1152/ajpheart.1995.269.4.H1282. PMID: 7485559.

• Akahori T et al. Role of a sialyl Lewis(x)-like epitope selectively expressed on vascular endothelial cells in local skin inflammation of the rat. J Immunol. 1997 Jun 1;158:(11):5384-92. PMID: 9164959.

• Bistrup A et al. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. J Cell Biol. 1999 May 17;145:(4):899-910. doi: 10.1083/jcb.145.4.899. PMID: 10330415.

• Hemmerich S et al. Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody. J Exp Med. 1994 Dec 1;180:(6):2219-26. doi: 10.1084/jem.180.6.2219. PMID: 7525849.

• Wagers AJ et al. Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes. J Immunol. 1997 Aug 15;159:(4):1917-29. PMID: 9257857.

• Kimura N et al. Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA. Proc Natl Acad Sci U S A. 1999 Apr 13;96:(8):4530-5. doi: 10.1073/pnas.96.8.4530. PMID: 10200296.

• Croce MV et al. Immunohistopathological characterizatin of spontaneous metastases in a human lung mucoepidermoid adenocarcinoma (HLMC) xenograft. Pathol Oncol Res. 1998;4:(4):259-66. doi: 10.1007/BF02905215. PMID: 9887355.

• Nakagoe T et al. Increased expression of sialyl Lewis(x) antigen in penetrating growth type A early gastric cancer. J Exp Clin Cancer Res. 2002 Sep;21:(3):363-9. PMID: 12385579.

• Hemmerich S et al. 6'-sulfated sialyl Lewis x is a major capping group of GlyCAM-1. Biochemistry. 1994 Apr 26;33:(16):4830-5. doi: 10.1021/bi00182a011. PMID: 8161542.

• Hiraoka N et al. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing. J Biol Chem. 2004 Jan 23;279:(4):3058-67. doi: 10.1074/jbc.M311150200. PMID: 14593101.

• Cai S et al. Complement regulatory protein C1 inhibitor binds to selectins and interferes with endothelial-leukocyte adhesion. J Immunol. 2003 Nov 1;171:(9):4786-91. doi: 10.4049/jimmunol.171.9.4786. PMID: 14568956.

• Mitsuoka C et al. Sulfated sialyl Lewis X, the putative L-selectin ligand, detected on endothelial cells of high endothelial venules by a distinct set of anti-sialyl Lewis X antibodies. Biochem Biophys Res Commun. 1997 Jan 23;230:(3):546-51. doi: 10.1006/bbrc.1996.6012. PMID: 9015359.

• Takaeda M et al. High endothelial venule-like vessels in the interstitial lesions of human glomerulonephritis. Am J Nephrol. 2002 Jan-Feb;22:(1):48-57. doi: 10.1159/000046674. PMID: 11919403.

• Mitsuoka C et al. Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis X. J Biol Chem. 1998 May 1;273:(18):11225-33. doi: 10.1074/jbc.273.18.11225. PMID: 9556613.

• Suematsu M et al. Impairment of selectin-mediated leukocyte adhesion to venular endothelium in spontaneously hypertensive rats. J Clin Invest. 1995 Oct;96:(4):2009-16. doi: 10.1172/JCI118248. PMID: 7560094.