fucosyltransferase 8

Summary
Gene Symbol
  • FUT8
Aliases
  • alpha (1,6) fucosyltransferase
Organism
Homo sapiens (human)
External Links
NCBI Gene
2530
GGDB ID
HGNC
4019
mRNA
map
  • 14q24.3
Protein
OMIM
KEGG Gene ID
hsa:2530
PubChem
2530
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Coiled coil
  • Congenital disorder of glycosylation
  • Disease variant
  • Disulfide bond
  • Glycosyltransferase
  • Golgi apparatus
  • Phosphoprotein
  • Reference proteome
  • SH3 domain
  • SH3-binding
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying all 3 entries
UniProt Protein Name
Q546E0
Q9BYC5
  • Fucosyltransferase 8
  • GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
  • GDP-fucose--glycoprotein fucosyltransferase
  • Glycoprotein 6-alpha-L-fucosyltransferase
A8K8P8
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000033170

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg009
Gene Symbol
  • FUT8
Reactions
Displaying 1 entry
Donor Acceptor Product Reference
GDP-Fuc
G39213VZ
G80858MF
Orthologous Gene
KEGG BRITE Database
Orthology
K00717
Name
glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
References
Reactions
Displaying all 2 entries
KEGG Reaction Enzyme Acceptor Product
R09319
R05988
Disease
Disease Ontology
Displaying entries 1 - 10 of 65 in total
DO ID Disease Name Source
DOID:0060249 scoliosis
DOID:0080199 colorectal carcinoma
DOID:10283 prostate cancer
DOID:10286 prostate carcinoma
DOID:1059 intellectual disability
DOID:1068 juvenile glaucoma
DOID:10907 microcephaly
DOID:11211 buphthalmos
DOID:11212 hydrophthalmos
DOID:11832 visual epilepsy
The Human Phenotype Ontology
Displaying entries 1 - 10 of 33 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000121 Nephrocalcinosis
HP:0000218 High palate
HP:0000252 Microcephaly
HP:0000278 Retrognathia
HP:0000337 Broad forehead
HP:0000341 Narrow forehead
HP:0000348 High forehead
HP:0000431 Wide nasal bridge
HP:0000501 Glaucoma
Displaying 1 entry
Disease ID Disease Name
OMIM:618005
  • congenital disorder of glycosylation with defective fucosylation 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024