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Coagulation factor XII
Summary
- UniProt ID
- D3ZTE0
- Gene Symbol
-
- F12
- Gene ID
- 306761
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Disulfide bond
- EGF-like domain
- Fibrinolysis
- Glycoprotein
- Kringle
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| rough endoplasmic reticulum |
| GO Term |
|---|
| serine-type endopeptidase activity |
| calcium ion binding |
| peptidase activity |
Sequence
MTALLFLGSLLMSLDLTLSAPPWKSKEFKDGAGDPSVVLTVDGKLCHFPFQYHRRLYHKCIHKGQPGSRPWCATTPNFDEDQQWGYCLEPKKVKDHCSKHSPCHKGGTCVNTPNGPHCLCPEHLTGKHCQREKCFESQLLKFFHENEIWFRTGPGGVARCQCKGPQAVCKLLTSQVCRVNPCLNGGTCLLVEDHRLCHCPAGYAGPFCDLDLKATCYEDRGLSYRGQAKTTLSGAPCQRWASEATYRNMTETQALSWGLGHHAFCRNPDNDTRPWCYVWSGDRLSWDYCDLEQCQMPTLTSPVSPESHDMLKPRPPILQSSPRDSTRNQNVVSRTSTVVCGQRFRKRLSSLRRVVGGLVALPGSHPYIAALYWGDSFCAGSLIDPCWVLTAAHCLQKRPAPEELTVVLGQDRHNQSCERCQTLAVHSYRLHEGFSSKTYQHDLALLRLRGRKNSCAILSPHVQPVCLPSSAAPPSETVLCEVAGWGHQFEGAEEYATFLQEAQVPFISLDRCSSSNVHGDAILPGMLCAGFLEGGADACQGDSGGPLVCDEGVTERQLTLRGVISWGSGCGDRNKPGVYTDVANYLDWIQEHTAF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 108 | O-linked (Fuc) threonine |
|
||
| 248 | N-linked (GlcNAc...) asparagine |
|
||
| 298 | O-linked (GalNAc...) threonine |
|
||
| 307 | O-linked (GalNAc...) serine |
|
||
| 326 | O-linked (GalNAc...) threonine |
|
||
| 414 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Intrinsic Pathway of Fibrin Clot Formation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9279 | hyperhomocysteinemia |
