Intrinsic Pathway of Fibrin Clot Formation

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
C1q binding protein tetramerKNG:C1q binding protein tetramerKng1prekallikrein:kininogen:C1q binding protein tetramerKlkb1kallikrein:kininogen:C1q binding protein tetramerKng1Plasma kallikreinactivated kininogen:C1q binding protein tetramerF12factor XIIafactor XIfactor XI:GPIb-IX-V complexGPIb-IX-Vfactor XIa:GPIb:GPIX:GPV complexP16296P16296factor IXaP16296F8factor VIIIactivated thrombin (factor IIa)Factor IIa inhibitors (compounds):IIaFactor IIa inhibitors (compounds)Factor IIa inhibitors (peptide)Factor IIa inhibitors (peptide):IIafactor VIIIafactor VIIIafactor IXafactor VIIIa:factor IXaCa2+factor XaF10factor Xfactor VIIIa A1:A3-C1-C2F8Q6P734Q6P734kallikrein:C1Inhfactor XIIa:C1Inhkallikrein:alpha2-macroglobulinA2M tetramer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 13 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
D3ZTE0 Coagulation factor XII
  • F12
view
O08770 Platelet glycoprotein V
  • Gp5
view
P06238 Alpha-2-macroglobulin
  • A2m
  • A2m1
view
P07092 Glia-derived nexin
  • Pi7
  • Pn1
  • Serpine2
view
P08934 Kininogen-1
  • Kng
  • Kng1
view
P14272 Plasma kallikrein
  • Klk3
  • Klkb1
  • Pk
view
P16296 Coagulation factor IX
  • Cf9
  • F9
view
P18292 Prothrombin
  • F2
view
P31394 Vitamin K-dependent protein C
  • Proc
view
P53813 Vitamin K-dependent protein S
  • Pros
  • Pros1
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025