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Alpha-2-macroglobulin

Summary

UniProt ID

P06238

Gene Symbol

A2m
A2m1

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P06238

Annotation

Keyword

Acute phase
Bait region
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
stem cell differentiation
response to glucocorticoid
embryonic liver development
negative regulation of complement activation, lectin pathway
acute inflammatory response to antigenic stimulus
response to nutrient
acute-phase response
luteinization
response to carbon dioxide
response to prostaglandin E

Displaying 1 entry
GO Term
extracellular space

Displaying entries **1 - 10** of 13 in total

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GO Term
protease binding
signaling receptor binding
enzyme binding
growth factor binding
tumor necrosis factor binding
nerve growth factor binding
calcium-dependent protein binding
identical protein binding
brain-derived neurotrophic factor binding
endopeptidase inhibitor activity

Annotation information from UniProt.

Sequence

MGKHRLRSLALLPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLHAGTPEKACFLFSHLNETVAVRVSLESVRGNQSLFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKPIYKPGQTVRFRVVSLDESFHPLNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTVNICRKYSNPSNCFGEESVAFCEKLSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVHAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDSHFRQGIPFVGQVLLVDGRGTPIPYETIFIGADEANLYINTTTDKHGLARFSINTDDIMGTSLTVRAKYKDSNACYGFRWLTEENVEAWHTAYAVFSPSRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKELVFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELSASLIYDLLPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNSNIRKPKVCERLRDNKGIPAAYHLVSQSHMDAFLESSESPTETRRSYFPETWIWDLVVVDSAGVAEVEVTVPDTITEWKAGAFCLSNDTGLGLSPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRVAVQLEASPDFLAAPEEKEQRSHCICMNQRHTASWAVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTFNSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKPGRNHANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEEDSVHWTRPQKPSVSVALWYQPQAPSAEVEMTAYVLLAYLTTEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSATFTRAKKAAQVTIHSSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYSVLPREEEFPFTVVVQTLPGTCEDPKAHTSFQISLNISYTGSRSESNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIPIRDLKPAVVKVYDYYEKDEFAVAKYSAPCSTDYGNA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 11 in total

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Position	Description	Source
59	N-linked (GlcNAc...) asparagine	UniProt
74	N-linked (GlcNAc...) asparagine	UniProt
250	N-linked (GlcNAc...) asparagine	UniProt
399	N-linked (GlcNAc...) asparagine	UniProt
651	N-linked (GlcNAc...) asparagine	UniProt
772	N-linked (GlcNAc...) asparagine	UniProt
867	N-linked (GlcNAc...) asparagine	UniProt
989	N-linked (GlcNAc...) asparagine	UniProt
1364	N-linked (GlcNAc...) asparagine	UniProt
1422	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Degradation of the extracellular matrix	Rattus norvegicus
HDL assembly	Rattus norvegicus
Intrinsic Pathway of Fibrin Clot Formation	Rattus norvegicus
Platelet degranulation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements