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Alpha-2-macroglobulin

Summary

UniProt ID

P06238

Gene Symbol

A2m
A2m1

Gene ID

24153

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P06238
Re-Glyco: P06238

Annotation

Keyword

Acute phase
Bait region
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Gene Ontology (GO)

Displaying 1 entry
GO Term
extracellular space

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 10** entries
GO Term
acute-phase response
response to nutrient
response to prostaglandin E
response to glucocorticoid
embryonic liver development
response to carbon dioxide
stem cell differentiation
luteinization
negative regulation of complement activation, lectin pathway
acute inflammatory response to antigenic stimulus

Displaying entries **1 - 10** of 13 in total

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GO Term
protease binding
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
growth factor binding
enzyme binding
identical protein binding
interleukin-1 binding
calcium-dependent protein binding
tumor necrosis factor binding
nerve growth factor binding

Annotation information from UniProt.

Sequence

MGKHRLRSLALLPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLHAGTPEKACFLFSHLNETVAVRVSLESVRGNQSLFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKPIYKPGQTVRFRVVSLDESFHPLNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTVNICRKYSNPSNCFGEESVAFCEKLSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVHAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDSHFRQGIPFVGQVLLVDGRGTPIPYETIFIGADEANLYINTTTDKHGLARFSINTDDIMGTSLTVRAKYKDSNACYGFRWLTEENVEAWHTAYAVFSPSRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKELVFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELSASLIYDLLPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNSNIRKPKVCERLRDNKGIPAAYHLVSQSHMDAFLESSESPTETRRSYFPETWIWDLVVVDSAGVAEVEVTVPDTITEWKAGAFCLSNDTGLGLSPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRVAVQLEASPDFLAAPEEKEQRSHCICMNQRHTASWAVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTFNSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKPGRNHANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEEDSVHWTRPQKPSVSVALWYQPQAPSAEVEMTAYVLLAYLTTEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSATFTRAKKAAQVTIHSSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYSVLPREEEFPFTVVVQTLPGTCEDPKAHTSFQISLNISYTGSRSESNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIPIRDLKPAVVKVYDYYEKDEFAVAKYSAPCSTDYGNA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 11 in total

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Position	Description	Source
59	N-linked (GlcNAc...) asparagine	UniProt
74	N-linked (GlcNAc...) asparagine	UniProt
250	N-linked (GlcNAc...) asparagine	UniProt
399	N-linked (GlcNAc...) asparagine	UniProt
651	N-linked (GlcNAc...) asparagine	UniProt
772	N-linked (GlcNAc...) asparagine	UniProt
867	N-linked (GlcNAc...) asparagine	UniProt
989	N-linked (GlcNAc...) asparagine	UniProt
1364	N-linked (GlcNAc...) asparagine	UniProt
1422	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Degradation of the extracellular matrix	Rattus norvegicus
HDL assembly	Rattus norvegicus
Intrinsic Pathway of Fibrin Clot Formation	Rattus norvegicus
Platelet degranulation	Rattus norvegicus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:583	hemolytic anemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements