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Prothrombin
Summary
- UniProt ID
- P18292
- Gene Symbol
-
- F2
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Acute phase
- Blood coagulation
- Calcium
- Cleavage on pair of basic residues
- Disulfide bond
- Gamma-carboxyglutamic acid
- Glycoprotein
- Kringle
- Reference proteome
- Repeat
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| collagen-containing extracellular matrix |
| external side of plasma membrane |
Sequence
MLHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cell surface interactions at the vascular wall | Rattus norvegicus |
| Common Pathway of Fibrin Clot Formation | Rattus norvegicus |
| G alpha (q) signalling events | Rattus norvegicus |
| Gamma-carboxylation of protein precursors | Rattus norvegicus |
| Intrinsic Pathway of Fibrin Clot Formation | Rattus norvegicus |
| Peptide ligand-binding receptors | Rattus norvegicus |
| Platelet Aggregation (Plug Formation) | Rattus norvegicus |
| Regulation of Complement cascade | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060903 | thrombosis | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:1936 | atherosclerosis | |
| DOID:2452 | thrombophilia | |
| DOID:2527 | nephrosis | |
| DOID:3070 | high grade glioma | |
| DOID:783 | end stage renal disease | |
| DOID:9279 | hyperhomocysteinemia | |
| DOID:9970 | obesity |
