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GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
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Guidelines
MIRAGE
Toll-like receptor 4
Summary
- UniProt ID
- O00206
- Gene Symbol
-
- TLR4
- Gene ID
- 7099
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O00206
- PubChem
- O00206
- The Human Metabolome Database
- HMDBP02639
- Re-Glyco
- O00206
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cell membrane
- Cell projection
- Direct protein sequencing
- Disulfide bond
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
Sequence
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 35 | N-linked (GlcNAc...) asparagine |
|
||
| 173 | N-linked (GlcNAc...) asparagine |
|
||
| 205 | N-linked (GlcNAc...) asparagine |
|
||
| 282 | N-linked (GlcNAc...) asparagine |
|
||
| 309 | N-linked (GlcNAc...) asparagine |
|
||
| 497 | N-linked (GlcNAc...) asparagine |
|
||
| 526 | N-linked (GlcNAc...) asparagine |
|
||
| 575 | N-linked (GlcNAc...) asparagine |
|
||
| 624 | N-linked (GlcNAc...) asparagine |
|
||
| 630 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| RSV-host interactions | Homo sapiens |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | Homo sapiens |
| Regulation of TLR by endogenous ligand | Homo sapiens |
| Respiratory syncytial virus (RSV) attachment and entry | Homo sapiens |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | Homo sapiens |
| TRIF-mediated programmed cell death | Homo sapiens |
| Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3042 | allergic contact dermatitis | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3310 | atopic dermatitis | |
| DOID:3393 | coronary artery disease | |
| DOID:3407 | carotid artery disease | |
| DOID:4448 | macular degeneration | |
| DOID:4481 | allergic rhinitis | |
| DOID:4677 | keratitis | |
| DOID:5844 | myocardial infarction | |
| DOID:684 | hepatocellular carcinoma |
