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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Neurocan core protein
Summary
- UniProt ID
- O14594
- Gene Symbol
-
- NCAN
- CSPG3
- NEUR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Calcium
- Cell adhesion
- Disulfide bond
- EGF-like domain
- Hyaluronic acid
- Immunoglobulin domain
- Lectin
- Proteoglycan
- Reference proteome
- Repeat
- Secreted
- Signal
- Sushi
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of neuroblast proliferation |
| skeletal system development |
| cell adhesion |
| central nervous system development |
| glial cell differentiation |
| GO Term |
|---|
| Golgi lumen |
| extracellular region |
| extracellular space |
| synapse |
| lysosomal lumen |
| perineuronal net |
| GO Term |
|---|
| calcium ion binding |
| carbohydrate binding |
| hyaluronic acid binding |
Sequence
MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCLFTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRRANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQEACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSYGRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEGLDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHHPTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATPDLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAHGEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAEHSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQDPWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDASGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPEPEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLLPVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGHENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRSNGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNFC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 122 | N-linked (GlcNAc...) asparagine | |||
| 124 |
|
|||
| 340 | N-linked (GlcNAc...) asparagine |
|
||
| 381 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 411 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 432 |
|
|
||
| 473 |
|
|
||
| 648 |
|
|
||
| 725 |
|
|||
| 768 |
|
|
G25418HZ
G39619TI
G51640FO
G56610MH
G20210JR
G50372IH
G01650EU
G23294PN
G48584BU
G80920RR
G03574QJ
G84820NF
G14260UH
G72735IY
G05724UK
G39188ZX
G25637MV
G06110VR
G00406II
G49108TO
G43417UB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| CS/DS degradation | Homo sapiens |
| Chondroitin sulfate biosynthesis | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective CHST14 causes EDS, musculocontractural type | Homo sapiens |
| Defective CHST3 causes SEDCJD | Homo sapiens |
| Defective CHSY1 causes TPBS | Homo sapiens |
| Dermatan sulfate biosynthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
