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Telomerase reverse transcriptase

Summary

UniProt ID

O14746

Gene Symbol

TERT
EST2
TCS1
TRT

Organism

Homo sapiens (human)

External Links

GlyGen: O14746
PubChem: O14746
The Human Metabolome Database: HMDBP02739
The O-GlcNAc Database: O14746

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA-binding
Disease variant
Dyskeratosis congenita
Magnesium
Metal-binding
Nucleus
Phosphoprotein
RNA-directed DNA polymerase
Reference proteome
Ribonucleoprotein
Telomere
Ubl conjugation

Gene Ontology (GO)

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GO Term
negative regulation of gene expression
positive regulation of angiogenesis
positive regulation of protein binding
positive regulation of hair cycle
negative regulation of neuron apoptotic process
DNA biosynthetic process
positive regulation of vascular associated smooth muscle cell proliferation
positive regulation of protein localization to nucleolus
positive regulation of vascular associated smooth muscle cell migration
negative regulation of endothelial cell apoptotic process

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GO Term
nucleus
nucleolus
plasma membrane
TERT-RMRP complex
PML body
nuclear speck
RNA-directed RNA polymerase complex
chromosome, telomeric region
cytosol
mitochondrial nucleoid

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GO Term
DNA binding
RNA binding
metal ion binding
protein-folding chaperone binding
identical protein binding
protein homodimerization activity
tRNA binding
transcription coactivator binding
telomerase activity
telomerase RNA reverse transcriptase activity

Annotation information from UniProt.

Sequence

MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Formation of the beta-catenin:TCF transactivating complex	Homo sapiens
Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence	Homo sapiens
Telomere Extension By Telomerase	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements