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MIRAGE
Inhibitor of nuclear factor kappa-B kinase subunit beta
Summary
- UniProt ID
- O14920
- Gene Symbol
-
- IKBKB
- IKKB
- Gene ID
- 3551
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Membrane
- Nucleus
- Phosphoprotein
- Reference proteome
- S-nitrosylation
- SCID
- Serine/threonine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| IkappaB kinase complex |
| CD40 receptor complex |
| nucleus |
| cytoplasm |
| cytosol |
| cytoplasmic side of plasma membrane |
| membrane raft |
Sequence
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 471 |
|
|||
| 733 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of NF-kappaB in B cells | Homo sapiens |
| CLEC7A (Dectin-1) signaling | Homo sapiens |
| Downstream TCR signaling | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| FCERI mediated NF-kB activation | Homo sapiens |
| IKBKB deficiency causes SCID | Homo sapiens |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | Homo sapiens |
| IKK complex recruitment mediated by RIP1 | Homo sapiens |
| IRAK1 recruits IKK complex | Homo sapiens |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111959 | immunodeficiency 15B | |
| DOID:0111960 | immunodeficiency 15A | |
| DOID:10283 | prostate cancer | |
| DOID:1612 | breast cancer | |
| DOID:2526 | prostate adenocarcinoma | |
| DOID:2723 | dermatitis | |
| DOID:3571 | liver cancer | |
| DOID:9352 | type 2 diabetes mellitus |
